Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population
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2010
Authors
Dimitrijević, RajnaCadez, Ivana
Keckarević-Marković, Milica
Keckarević, Dušan
Kecmanović, Miljana
Dobričić, Valerija
Savić-Pavićević, Dušanka
Brajusković, Goran
Romac, Stanka
Article (Published version)
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Show full item recordAbstract
Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.
Keywords:
E219K / M129V / polymorphism / prion diseases / PRNP / Serbian populationSource:
International Journal of Neuroscience, 2010, 120, 7, 496-501Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Molekularna genetika naslednih neurodegenerativnih i psihijatrijskih oboljenja (RS-MESTD-MPN2006-2010-143013)
DOI: 10.3109/00207451003765907
ISSN: 0020-7454
PubMed: 20583902
WoS: 000279487800005
Scopus: 2-s2.0-77954180773
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TorlakTY - JOUR AU - Dimitrijević, Rajna AU - Cadez, Ivana AU - Keckarević-Marković, Milica AU - Keckarević, Dušan AU - Kecmanović, Miljana AU - Dobričić, Valerija AU - Savić-Pavićević, Dušanka AU - Brajusković, Goran AU - Romac, Stanka PY - 2010 UR - http://intor.torlakinstitut.com/handle/123456789/299 AB - Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population EP - 501 IS - 7 SP - 496 VL - 120 DO - 10.3109/00207451003765907 ER -
@article{ author = "Dimitrijević, Rajna and Cadez, Ivana and Keckarević-Marković, Milica and Keckarević, Dušan and Kecmanović, Miljana and Dobričić, Valerija and Savić-Pavićević, Dušanka and Brajusković, Goran and Romac, Stanka", year = "2010", abstract = "Prion diseases are a group of etiologically heterogenous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism. For Serbian population, polymorphism of PRNP gene at codon 129 does not differ from healthy European populations. Also codon 219 is monomorphic for the Glu allele both in Serbian population and other European populations. On the contrary, in Serbian population we did not detect any deletions or insertions in octapeptide repeat region, whereas deletions were detected in other European populations.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population", pages = "501-496", number = "7", volume = "120", doi = "10.3109/00207451003765907" }
Dimitrijević, R., Cadez, I., Keckarević-Marković, M., Keckarević, D., Kecmanović, M., Dobričić, V., Savić-Pavićević, D., Brajusković, G.,& Romac, S.. (2010). Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 120(7), 496-501. https://doi.org/10.3109/00207451003765907
Dimitrijević R, Cadez I, Keckarević-Marković M, Keckarević D, Kecmanović M, Dobričić V, Savić-Pavićević D, Brajusković G, Romac S. Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population. in International Journal of Neuroscience. 2010;120(7):496-501. doi:10.3109/00207451003765907 .
Dimitrijević, Rajna, Cadez, Ivana, Keckarević-Marković, Milica, Keckarević, Dušan, Kecmanović, Miljana, Dobričić, Valerija, Savić-Pavićević, Dušanka, Brajusković, Goran, Romac, Stanka, "Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population" in International Journal of Neuroscience, 120, no. 7 (2010):496-501, https://doi.org/10.3109/00207451003765907 . .