Strain differences in peritoneal macrophage activity and susceptibility to experimental allergic encephalomyelitis induction in rats
Samo za registrovane korisnike
2007
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The objective of the present study was to investigate the relevance of peripheral macrophage activity for the susceptibility to the induction of experimental allergic encephalomyelitis (EAE). Rats of EAE-susceptible Dark Agouti and EAEresistant Albino Oxford strain were immunized with guinea pig spinal cord homogenate (DA(GPSC) and AO(GPSC)), while non-immunized rats served as controls (DA(NIM), AO(NIM))- On day 15 after immunization rats were sacrificed and their peritoneal macrophages tested for adherence capacity, zymosan phagocytosis and respiratory burst. Macrophages from AO(NIM) rats exhibited lower adherence capacity and higher phagocytosis and H2O2 production when compared to macrophages from DA(NIM) rats. Immunization with GPSC decreased adherence and phagocytosis and increased H2O2 production in macrophages from AO rats, but did not influence these activities in macrophages from DA rats. The results from the present study suggest that inflammatory activities of macrophages fr...om AO rats could be considered as regulatory mechanisms connected with the resistance to EAE induction.
Izvor:
Inflammation Research, 2007, 56, S495-S498Izdavač:
- Springer Basel Ag, Basel
Finansiranje / projekti:
- Neuroendokrina modulacija imunskog odgovora: uloga simpato-adrenomedularnog sistema (RS-MESTD-MPN2006-2010-145049)
DOI: 10.1007/BF03353888
ISSN: 1023-3830
WoS: 000247517900339
Scopus: 2-s2.0-50249159749
Institucija/grupa
TorlakTY - JOUR AU - Mitić, Katarina AU - Stanojević, Stanislava AU - Kuštrimović, Nataša AU - Dimitrijević, Mirjana PY - 2007 UR - http://intor.torlakinstitut.com/handle/123456789/234 AB - The objective of the present study was to investigate the relevance of peripheral macrophage activity for the susceptibility to the induction of experimental allergic encephalomyelitis (EAE). Rats of EAE-susceptible Dark Agouti and EAEresistant Albino Oxford strain were immunized with guinea pig spinal cord homogenate (DA(GPSC) and AO(GPSC)), while non-immunized rats served as controls (DA(NIM), AO(NIM))- On day 15 after immunization rats were sacrificed and their peritoneal macrophages tested for adherence capacity, zymosan phagocytosis and respiratory burst. Macrophages from AO(NIM) rats exhibited lower adherence capacity and higher phagocytosis and H2O2 production when compared to macrophages from DA(NIM) rats. Immunization with GPSC decreased adherence and phagocytosis and increased H2O2 production in macrophages from AO rats, but did not influence these activities in macrophages from DA rats. The results from the present study suggest that inflammatory activities of macrophages from AO rats could be considered as regulatory mechanisms connected with the resistance to EAE induction. PB - Springer Basel Ag, Basel T2 - Inflammation Research T1 - Strain differences in peritoneal macrophage activity and susceptibility to experimental allergic encephalomyelitis induction in rats EP - S498 SP - S495 VL - 56 DO - 10.1007/BF03353888 ER -
@article{ author = "Mitić, Katarina and Stanojević, Stanislava and Kuštrimović, Nataša and Dimitrijević, Mirjana", year = "2007", abstract = "The objective of the present study was to investigate the relevance of peripheral macrophage activity for the susceptibility to the induction of experimental allergic encephalomyelitis (EAE). Rats of EAE-susceptible Dark Agouti and EAEresistant Albino Oxford strain were immunized with guinea pig spinal cord homogenate (DA(GPSC) and AO(GPSC)), while non-immunized rats served as controls (DA(NIM), AO(NIM))- On day 15 after immunization rats were sacrificed and their peritoneal macrophages tested for adherence capacity, zymosan phagocytosis and respiratory burst. Macrophages from AO(NIM) rats exhibited lower adherence capacity and higher phagocytosis and H2O2 production when compared to macrophages from DA(NIM) rats. Immunization with GPSC decreased adherence and phagocytosis and increased H2O2 production in macrophages from AO rats, but did not influence these activities in macrophages from DA rats. The results from the present study suggest that inflammatory activities of macrophages from AO rats could be considered as regulatory mechanisms connected with the resistance to EAE induction.", publisher = "Springer Basel Ag, Basel", journal = "Inflammation Research", title = "Strain differences in peritoneal macrophage activity and susceptibility to experimental allergic encephalomyelitis induction in rats", pages = "S498-S495", volume = "56", doi = "10.1007/BF03353888" }
Mitić, K., Stanojević, S., Kuštrimović, N.,& Dimitrijević, M.. (2007). Strain differences in peritoneal macrophage activity and susceptibility to experimental allergic encephalomyelitis induction in rats. in Inflammation Research Springer Basel Ag, Basel., 56, S495-S498. https://doi.org/10.1007/BF03353888
Mitić K, Stanojević S, Kuštrimović N, Dimitrijević M. Strain differences in peritoneal macrophage activity and susceptibility to experimental allergic encephalomyelitis induction in rats. in Inflammation Research. 2007;56:S495-S498. doi:10.1007/BF03353888 .
Mitić, Katarina, Stanojević, Stanislava, Kuštrimović, Nataša, Dimitrijević, Mirjana, "Strain differences in peritoneal macrophage activity and susceptibility to experimental allergic encephalomyelitis induction in rats" in Inflammation Research, 56 (2007):S495-S498, https://doi.org/10.1007/BF03353888 . .