The possible role of natural idiotopes in immune memory
Аутори
Dimitrijević, LjiljanaŽivančević-Simonović, Snežana
Stojanović, Marijana
Inić-Kanada, Aleksandra
Živković, Irena
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens. The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Absl and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system h...ave inspired us in our attempt at explaining the possible role of natural Id in immune memory.
Кључне речи:
Anti-Id / Idiotope / Natural memory / NetworkИзвор:
Clinical and Developmental Immunology, 2004, 11, 3-4, 281-285Издавач:
- Taylor and Francis Ltd.
DOI: 10.1080/17402520400001645
ISSN: 1740-2522
PubMed: 15559375
Scopus: 2-s2.0-7244234571
Институција/група
TorlakTY - CONF AU - Dimitrijević, Ljiljana AU - Živančević-Simonović, Snežana AU - Stojanović, Marijana AU - Inić-Kanada, Aleksandra AU - Živković, Irena PY - 2004 UR - http://intor.torlakinstitut.com/handle/123456789/177 AB - In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens. The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Absl and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system have inspired us in our attempt at explaining the possible role of natural Id in immune memory. PB - Taylor and Francis Ltd. C3 - Clinical and Developmental Immunology T1 - The possible role of natural idiotopes in immune memory EP - 285 IS - 3-4 SP - 281 VL - 11 DO - 10.1080/17402520400001645 ER -
@conference{ author = "Dimitrijević, Ljiljana and Živančević-Simonović, Snežana and Stojanović, Marijana and Inić-Kanada, Aleksandra and Živković, Irena", year = "2004", abstract = "In this paper we report on the generation of Abs possessing specificities similar to those of Abs used in immunization, and on the generation of Id and anti-Id specificities in the sera of mice immunized with commensal bacterial antigens. The human monoclonal antibody IgM DJ (VH3/VL2) expresses natural antibody properties, natural idiotope (Y7), and specificity towards Lactic acid bacteria (LAB). When used in immunization it generates LAB-specific antibodies. Immunization with LAB, as detected in the presence of biotin-labelled mouse monoclonal anti-idiotopic antibodies Y7 and IgM DJ generates Absl and Abs2, respectively. These findings may imply that the recognition of bacterial motifs accords with the rules of idiotypic network theory. This theory, first proposed by Jerne in 1974 and often overlooked since, has been subject to change during the course of immunological research. Recent experiments concerning the recognition of bacterial motifs and natural memory in the immune system have inspired us in our attempt at explaining the possible role of natural Id in immune memory.", publisher = "Taylor and Francis Ltd.", journal = "Clinical and Developmental Immunology", title = "The possible role of natural idiotopes in immune memory", pages = "285-281", number = "3-4", volume = "11", doi = "10.1080/17402520400001645" }
Dimitrijević, L., Živančević-Simonović, S., Stojanović, M., Inić-Kanada, A.,& Živković, I.. (2004). The possible role of natural idiotopes in immune memory. in Clinical and Developmental Immunology Taylor and Francis Ltd.., 11(3-4), 281-285. https://doi.org/10.1080/17402520400001645
Dimitrijević L, Živančević-Simonović S, Stojanović M, Inić-Kanada A, Živković I. The possible role of natural idiotopes in immune memory. in Clinical and Developmental Immunology. 2004;11(3-4):281-285. doi:10.1080/17402520400001645 .
Dimitrijević, Ljiljana, Živančević-Simonović, Snežana, Stojanović, Marijana, Inić-Kanada, Aleksandra, Živković, Irena, "The possible role of natural idiotopes in immune memory" in Clinical and Developmental Immunology, 11, no. 3-4 (2004):281-285, https://doi.org/10.1080/17402520400001645 . .