Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats
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2003
Authors
Todorović, C.Dimitrijević, Mirjana
Stanojević, Stanislava
Kovačević-Jovanović, Vesna
Miletić, Tatjana
Laban, Olgica
Radulović, Jelena
Article (Published version)
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We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a comm...on neuroimmune regulatory mechanism.
Keywords:
analgesia / forced-swim test / macrophages / open field / plaque forming cell response / ratSource:
International Journal of Neuroscience, 2003, 113, 9, 1259-1273Publisher:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1080/00207450390212492
ISSN: 0020-7454
PubMed: 12959743
WoS: 000185728700007
Scopus: 2-s2.0-0141996941
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TorlakTY - JOUR AU - Todorović, C. AU - Dimitrijević, Mirjana AU - Stanojević, Stanislava AU - Kovačević-Jovanović, Vesna AU - Miletić, Tatjana AU - Laban, Olgica AU - Radulović, Jelena PY - 2003 UR - http://intor.torlakinstitut.com/handle/123456789/160 AB - We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats EP - 1273 IS - 9 SP - 1259 VL - 113 DO - 10.1080/00207450390212492 ER -
@article{ author = "Todorović, C. and Dimitrijević, Mirjana and Stanojević, Stanislava and Kovačević-Jovanović, Vesna and Miletić, Tatjana and Laban, Olgica and Radulović, Jelena", year = "2003", abstract = "We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats", pages = "1273-1259", number = "9", volume = "113", doi = "10.1080/00207450390212492" }
Todorović, C., Dimitrijević, M., Stanojević, S., Kovačević-Jovanović, V., Miletić, T., Laban, O.,& Radulović, J.. (2003). Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 113(9), 1259-1273. https://doi.org/10.1080/00207450390212492
Todorović C, Dimitrijević M, Stanojević S, Kovačević-Jovanović V, Miletić T, Laban O, Radulović J. Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats. in International Journal of Neuroscience. 2003;113(9):1259-1273. doi:10.1080/00207450390212492 .
Todorović, C., Dimitrijević, Mirjana, Stanojević, Stanislava, Kovačević-Jovanović, Vesna, Miletić, Tatjana, Laban, Olgica, Radulović, Jelena, "Correlation between age-related changes in open field behavior and plaque forming cell response in DA female rats" in International Journal of Neuroscience, 113, no. 9 (2003):1259-1273, https://doi.org/10.1080/00207450390212492 . .