Different effects of methionine-enkephalin on paw edema in two inbred rat strains
Само за регистроване кориснике
2002
Аутори
Stanojević, StanislavaRadulović, Jelena
Kovačević-Jovanović, Vesna
Vujić, Vesna
Dimitrijević, Mirjana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (kappa opioid receptors antagonist) and beta-funaltrexarnine (mu opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains. (C) 2002 Elsevier Science Inc. All rights reserved.
Кључне речи:
methionine-enkephalin / naloxone / naltrindole / nor-binaltorphimine / beta-funaltrexamine / concanavalin A / delta, kappa, mu opioid receptors / paw edema / rat strainИзвор:
Peptides, 2002, 23, 9, 1597-1605Издавач:
- Elsevier Science Inc, New York
DOI: 10.1016/S0196-9781(02)00105-5
ISSN: 0196-9781
PubMed: 12217420
WoS: 000178339300009
Scopus: 2-s2.0-0036710536
Институција/група
TorlakTY - JOUR AU - Stanojević, Stanislava AU - Radulović, Jelena AU - Kovačević-Jovanović, Vesna AU - Vujić, Vesna AU - Dimitrijević, Mirjana PY - 2002 UR - http://intor.torlakinstitut.com/handle/123456789/152 AB - The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (kappa opioid receptors antagonist) and beta-funaltrexarnine (mu opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains. (C) 2002 Elsevier Science Inc. All rights reserved. PB - Elsevier Science Inc, New York T2 - Peptides T1 - Different effects of methionine-enkephalin on paw edema in two inbred rat strains EP - 1605 IS - 9 SP - 1597 VL - 23 DO - 10.1016/S0196-9781(02)00105-5 ER -
@article{ author = "Stanojević, Stanislava and Radulović, Jelena and Kovačević-Jovanović, Vesna and Vujić, Vesna and Dimitrijević, Mirjana", year = "2002", abstract = "The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (kappa opioid receptors antagonist) and beta-funaltrexarnine (mu opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains. (C) 2002 Elsevier Science Inc. All rights reserved.", publisher = "Elsevier Science Inc, New York", journal = "Peptides", title = "Different effects of methionine-enkephalin on paw edema in two inbred rat strains", pages = "1605-1597", number = "9", volume = "23", doi = "10.1016/S0196-9781(02)00105-5" }
Stanojević, S., Radulović, J., Kovačević-Jovanović, V., Vujić, V.,& Dimitrijević, M.. (2002). Different effects of methionine-enkephalin on paw edema in two inbred rat strains. in Peptides Elsevier Science Inc, New York., 23(9), 1597-1605. https://doi.org/10.1016/S0196-9781(02)00105-5
Stanojević S, Radulović J, Kovačević-Jovanović V, Vujić V, Dimitrijević M. Different effects of methionine-enkephalin on paw edema in two inbred rat strains. in Peptides. 2002;23(9):1597-1605. doi:10.1016/S0196-9781(02)00105-5 .
Stanojević, Stanislava, Radulović, Jelena, Kovačević-Jovanović, Vesna, Vujić, Vesna, Dimitrijević, Mirjana, "Different effects of methionine-enkephalin on paw edema in two inbred rat strains" in Peptides, 23, no. 9 (2002):1597-1605, https://doi.org/10.1016/S0196-9781(02)00105-5 . .