Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat
Samo za registrovane korisnike
1999
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In the present study we investigated the effect of selectivity destroyed dopaminergic neurons of the caudate-putamen (CP) on immune reactivity in the rat. Unilateral and bilateral lesioning of CP was performed by one direct stereotaxic injection of 6-hydroxydopamine solution. Sham-lesioned and intact rats served as controls. Two weeks after the operation, the animals were immunized with sheep red blood cells or bovine serum albumin for determination of plaque forming cell-response and Arthus and delayed hypersensitivity skin reactions, respectively. Unilateral and bilateral lesions of CP considerably suppressed PFC-response and Arthus and delayed the hypersensitivity reactions in comparison to control rats, while no differences were observed between unilaterally and bilaterally lesioned animals. (C) 1999 Elsevier Science Ltd. All rights reserved.
Ključne reči:
6-hydroxydopamine / denervation / caudate-putamen / central dopaminergic system / immune response / immunityIzvor:
Parkinsonism & Related Disorders, 1999, 5, 1-2, 77-82Izdavač:
- Elsevier Sci Ltd, Oxford
DOI: 10.1016/S1353-8020(99)00014-0
ISSN: 1353-8020
PubMed: 18591124
WoS: 000082490100011
Scopus: 2-s2.0-0032988283
Institucija/grupa
TorlakTY - JOUR AU - Radojević, Katarina AU - Velikinac, S. AU - Rauški, Aleksandra AU - Vidić, Biljana AU - Jovanova-Nešić, Katica PY - 1999 UR - http://intor.torlakinstitut.com/handle/123456789/106 AB - In the present study we investigated the effect of selectivity destroyed dopaminergic neurons of the caudate-putamen (CP) on immune reactivity in the rat. Unilateral and bilateral lesioning of CP was performed by one direct stereotaxic injection of 6-hydroxydopamine solution. Sham-lesioned and intact rats served as controls. Two weeks after the operation, the animals were immunized with sheep red blood cells or bovine serum albumin for determination of plaque forming cell-response and Arthus and delayed hypersensitivity skin reactions, respectively. Unilateral and bilateral lesions of CP considerably suppressed PFC-response and Arthus and delayed the hypersensitivity reactions in comparison to control rats, while no differences were observed between unilaterally and bilaterally lesioned animals. (C) 1999 Elsevier Science Ltd. All rights reserved. PB - Elsevier Sci Ltd, Oxford T2 - Parkinsonism & Related Disorders T1 - Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat EP - 82 IS - 1-2 SP - 77 VL - 5 DO - 10.1016/S1353-8020(99)00014-0 ER -
@article{ author = "Radojević, Katarina and Velikinac, S. and Rauški, Aleksandra and Vidić, Biljana and Jovanova-Nešić, Katica", year = "1999", abstract = "In the present study we investigated the effect of selectivity destroyed dopaminergic neurons of the caudate-putamen (CP) on immune reactivity in the rat. Unilateral and bilateral lesioning of CP was performed by one direct stereotaxic injection of 6-hydroxydopamine solution. Sham-lesioned and intact rats served as controls. Two weeks after the operation, the animals were immunized with sheep red blood cells or bovine serum albumin for determination of plaque forming cell-response and Arthus and delayed hypersensitivity skin reactions, respectively. Unilateral and bilateral lesions of CP considerably suppressed PFC-response and Arthus and delayed the hypersensitivity reactions in comparison to control rats, while no differences were observed between unilaterally and bilaterally lesioned animals. (C) 1999 Elsevier Science Ltd. All rights reserved.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Parkinsonism & Related Disorders", title = "Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat", pages = "82-77", number = "1-2", volume = "5", doi = "10.1016/S1353-8020(99)00014-0" }
Radojević, K., Velikinac, S., Rauški, A., Vidić, B.,& Jovanova-Nešić, K.. (1999). Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat. in Parkinsonism & Related Disorders Elsevier Sci Ltd, Oxford., 5(1-2), 77-82. https://doi.org/10.1016/S1353-8020(99)00014-0
Radojević K, Velikinac S, Rauški A, Vidić B, Jovanova-Nešić K. Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat. in Parkinsonism & Related Disorders. 1999;5(1-2):77-82. doi:10.1016/S1353-8020(99)00014-0 .
Radojević, Katarina, Velikinac, S., Rauški, Aleksandra, Vidić, Biljana, Jovanova-Nešić, Katica, "Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat" in Parkinsonism & Related Disorders, 5, no. 1-2 (1999):77-82, https://doi.org/10.1016/S1353-8020(99)00014-0 . .