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dc.creatorSekulić, M.
dc.creatorLovren, M.
dc.creatorMilošević, V.
dc.creatorMicić, M.
dc.creatorBalint-Perić, L.
dc.date.accessioned2021-02-18T10:21:18Z
dc.date.available2021-02-18T10:21:18Z
dc.date.issued1998
dc.identifier.issn0948-6143
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/95
dc.description.abstractThe structure and function of C cells of middle-aged female rats (14-months old) treated with estradiol dipropionate (EDP), calcium (Ca) or a combination of EDP+Ca were studied. A stereological method was used to determine the volume of calcitonin (CT)-immunoreactive C cells and their nuclei, and the relative volume density and mean number of the C cells per section were calculated. Serum levels of CT, osteocalcin, parathyroid hormone (PTH), and beta-estradiol were also measured. A significant decrease in body weight of the rats treated with EDP or EDP+Ca was observed. These treatments led to a significant decrease in cellular and nuclear volumes, relative volume density, and mean number of C cells per section, in comparison with the corresponding controls. A reduction of the serum level of CT, PTH, and osteocalcin was also recorded in EDP-and EDP+Ca-treated animals. No statistically significant differences between Ca- and vehicle-injected rats, with regard to all morphometric C cell parameters and biochemical values determined, were seen. However, a conspicuous degranulation of the C cells and decreased immunoreactivity for CT in the Ca-receiving group, which could be interpreted as the signs of increased activity of these cells, were noticed. This effect of Ca was also observed in rats injected with EDP and Ca in combination, when the inhibitory effect of EDP on C cell function was less noticeable than in the group treated with EDP alone.en
dc.publisherSpringer, New York
dc.rightsrestrictedAccess
dc.sourceHistochemistry and Cell Biology
dc.titleThyroid C cells of middle-aged rats treated with estradiol or calciumen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage262
dc.citation.issue3
dc.citation.other109(3): 257-262
dc.citation.spage257
dc.citation.volume109
dc.identifier.doi10.1007/s004180050225
dc.identifier.pmid9541474
dc.identifier.rcubconv_77
dc.identifier.scopus2-s2.0-0031893683
dc.identifier.wos000072332600010
dc.type.versionpublishedVersion


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