The structure and function of C cells of middle-aged female rats (14-months old) treated with estradiol dipropionate (EDP), calcium (Ca) or a combination of EDP+Ca were studied. A stereological method was used to determine the volume of calcitonin (CT)-immunoreactive C cells and their nuclei, and the relative volume density and mean number of the C cells per section were calculated. Serum levels of CT, osteocalcin, parathyroid hormone (PTH), and beta-estradiol were also measured. A significant decrease in body weight of the rats treated with EDP or EDP+Ca was observed. These treatments led to a significant decrease in cellular and nuclear volumes, relative volume density, and mean number of C cells per section, in comparison with the corresponding controls. A reduction of the serum level of CT, PTH, and osteocalcin was also recorded in EDP-and EDP+Ca-treated animals. No statistically significant differences between Ca- and vehicle-injected rats, with regard to all morphometric C cell p...arameters and biochemical values determined, were seen. However, a conspicuous degranulation of the C cells and decreased immunoreactivity for CT in the Ca-receiving group, which could be interpreted as the signs of increased activity of these cells, were noticed. This effect of Ca was also observed in rats injected with EDP and Ca in combination, when the inhibitory effect of EDP on C cell function was less noticeable than in the group treated with EDP alone.
Source:
Histochemistry and Cell Biology, 1998, 109, 3, 257-262
TY - JOUR
AU - Sekulić, M.
AU - Lovren, M.
AU - Milošević, V.
AU - Micić, M.
AU - Balint-Perić, L.
PY - 1998
UR - http://intor.torlakinstitut.com/handle/123456789/95
AB - The structure and function of C cells of middle-aged female rats (14-months old) treated with estradiol dipropionate (EDP), calcium (Ca) or a combination of EDP+Ca were studied. A stereological method was used to determine the volume of calcitonin (CT)-immunoreactive C cells and their nuclei, and the relative volume density and mean number of the C cells per section were calculated. Serum levels of CT, osteocalcin, parathyroid hormone (PTH), and beta-estradiol were also measured. A significant decrease in body weight of the rats treated with EDP or EDP+Ca was observed. These treatments led to a significant decrease in cellular and nuclear volumes, relative volume density, and mean number of C cells per section, in comparison with the corresponding controls. A reduction of the serum level of CT, PTH, and osteocalcin was also recorded in EDP-and EDP+Ca-treated animals. No statistically significant differences between Ca- and vehicle-injected rats, with regard to all morphometric C cell parameters and biochemical values determined, were seen. However, a conspicuous degranulation of the C cells and decreased immunoreactivity for CT in the Ca-receiving group, which could be interpreted as the signs of increased activity of these cells, were noticed. This effect of Ca was also observed in rats injected with EDP and Ca in combination, when the inhibitory effect of EDP on C cell function was less noticeable than in the group treated with EDP alone.
PB - Springer, New York
T2 - Histochemistry and Cell Biology
T1 - Thyroid C cells of middle-aged rats treated with estradiol or calcium
EP - 262
IS - 3
SP - 257
VL - 109
DO - 10.1007/s004180050225
UR - conv_77
ER -
@article{
author = "Sekulić, M. and Lovren, M. and Milošević, V. and Micić, M. and Balint-Perić, L.",
year = "1998",
abstract = "The structure and function of C cells of middle-aged female rats (14-months old) treated with estradiol dipropionate (EDP), calcium (Ca) or a combination of EDP+Ca were studied. A stereological method was used to determine the volume of calcitonin (CT)-immunoreactive C cells and their nuclei, and the relative volume density and mean number of the C cells per section were calculated. Serum levels of CT, osteocalcin, parathyroid hormone (PTH), and beta-estradiol were also measured. A significant decrease in body weight of the rats treated with EDP or EDP+Ca was observed. These treatments led to a significant decrease in cellular and nuclear volumes, relative volume density, and mean number of C cells per section, in comparison with the corresponding controls. A reduction of the serum level of CT, PTH, and osteocalcin was also recorded in EDP-and EDP+Ca-treated animals. No statistically significant differences between Ca- and vehicle-injected rats, with regard to all morphometric C cell parameters and biochemical values determined, were seen. However, a conspicuous degranulation of the C cells and decreased immunoreactivity for CT in the Ca-receiving group, which could be interpreted as the signs of increased activity of these cells, were noticed. This effect of Ca was also observed in rats injected with EDP and Ca in combination, when the inhibitory effect of EDP on C cell function was less noticeable than in the group treated with EDP alone.",
publisher = "Springer, New York",
journal = "Histochemistry and Cell Biology",
title = "Thyroid C cells of middle-aged rats treated with estradiol or calcium",
pages = "262-257",
number = "3",
volume = "109",
doi = "10.1007/s004180050225",
url = "conv_77"
}
Sekulić, M., Lovren, M., Milošević, V., Micić, M.,& Balint-Perić, L.. (1998). Thyroid C cells of middle-aged rats treated with estradiol or calcium. in Histochemistry and Cell Biology
Springer, New York., 109(3), 257-262.
https://doi.org/10.1007/s004180050225
conv_77
Sekulić M, Lovren M, Milošević V, Micić M, Balint-Perić L. Thyroid C cells of middle-aged rats treated with estradiol or calcium. in Histochemistry and Cell Biology. 1998;109(3):257-262.
doi:10.1007/s004180050225
conv_77 .
Sekulić, M., Lovren, M., Milošević, V., Micić, M., Balint-Perić, L., "Thyroid C cells of middle-aged rats treated with estradiol or calcium" in Histochemistry and Cell Biology, 109, no. 3 (1998):257-262,
https://doi.org/10.1007/s004180050225 .,
conv_77 .
