Show simple item record

dc.creatorPopović, M.
dc.creatorPopović, N.
dc.creatorBokonjić, D.
dc.creatorDobrić, Silva
dc.creatorUgrešić, Nenad
dc.creatorKostić, V.S.
dc.date.accessioned2021-02-18T10:20:48Z
dc.date.available2021-02-18T10:20:48Z
dc.date.issued1998
dc.identifier.issn0893-6609
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/87
dc.description.abstractIn order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease.en
dc.publisherWiley, Hoboken
dc.rightsrestrictedAccess
dc.sourceNeuroscience Research Communications
dc.subjectAlzheimer's diseaseen
dc.subjectaggressionen
dc.subjectdepressionen
dc.subjectphysostigmineen
dc.subjectverapamilen
dc.subjectratsen
dc.titleEffect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularisen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage22
dc.citation.issue1
dc.citation.other23(1): 13-22
dc.citation.rankM23
dc.citation.spage13
dc.citation.volume23
dc.identifier.doi10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O
dc.identifier.rcubconv_90
dc.identifier.scopus2-s2.0-0031661621
dc.identifier.wos000075428000002
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record