In order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease.
TY - JOUR
AU - Popović, M.
AU - Popović, N.
AU - Bokonjić, D.
AU - Dobrić, Silva
AU - Ugrešić, Nenad
AU - Kostić, V.S.
PY - 1998
UR - http://intor.torlakinstitut.com/handle/123456789/87
AB - In order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease.
PB - Wiley, Hoboken
T2 - Neuroscience Research Communications
T1 - Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis
EP - 22
IS - 1
SP - 13
VL - 23
DO - 10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O
UR - conv_90
ER -
@article{
author = "Popović, M. and Popović, N. and Bokonjić, D. and Dobrić, Silva and Ugrešić, Nenad and Kostić, V.S.",
year = "1998",
abstract = "In order to investigate the effects of physostigmine and verapamil on aggressive (test of foot shock induced aggression) and depressive (learned helplessness test) behavior, ten days after bilateral lesions of the nucleus basalis magnocellularis (NBM), adult male Wistar rats were acute treated (30 min before the test) with physostigmine (0.045, 0.060 and 0.075 mg/kg, s.c.) or verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg, s.c.) Physostigmine in dose of 0.075 mg/kg and verapamil in doses 2.5 and 5.0 mg/kg significantly prolongated the escape latency period in the learned helplessness test and thus produced a consolidation of depressiveness in NBM-lesioned rats. Tn contrast to that, there was no restitution of aggressive behavior in NBM-lesioned rats treated with both drugs. It could be concluded that both physostigmine and verapamil exerts a significant influence on depressive, but not on aggressive reaction in an animal model of Alzheimer's disease.",
publisher = "Wiley, Hoboken",
journal = "Neuroscience Research Communications",
title = "Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis",
pages = "22-13",
number = "1",
volume = "23",
doi = "10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O",
url = "conv_90"
}
Popović, M., Popović, N., Bokonjić, D., Dobrić, S., Ugrešić, N.,& Kostić, V.S.. (1998). Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis. in Neuroscience Research Communications
Wiley, Hoboken., 23(1), 13-22.
https://doi.org/10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O
conv_90
Popović M, Popović N, Bokonjić D, Dobrić S, Ugrešić N, Kostić V. Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis. in Neuroscience Research Communications. 1998;23(1):13-22.
doi:10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O
conv_90 .
Popović, M., Popović, N., Bokonjić, D., Dobrić, Silva, Ugrešić, Nenad, Kostić, V.S., "Effect of acute physostigmine and verapamil treatment on aggressive and depressive behavior in rats with lesioned nucleus basalis magnocellularis" in Neuroscience Research Communications, 23, no. 1 (1998):13-22,
https://doi.org/10.1002/(SICI)1520-6769(199807/08)23:113::AID-NRC23.0.CO;2-O .,
conv_90 .
