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Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease

Authorized Users Only
1998
Authors
Popović, M.
Caballero-Bleda, M.
Puelles, L.
Popović, N.
Popović, N.
Article (Published version)
Metadata
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Abstract
The contribution of autoimmune processes or inflammatory components in the etiology and pathogenesis of Alzheimer's disease (AD) has been suspected for many years. The presence of antigen-presenting, HLA-DR-positive and other immunoregulatory cells, components of complement, inflammatory cytokines and acute phase reactants have been established in tissue of AD neuropathology. Although these data do not confirm the immune response as a primary cause of AD, they indicate involvement of immune processes at least as a secondary or tertiary reaction to the preexisting pathogen and point out its driving-force role in AD pathogenesis. These processes may contribute to systemic immune response. Thus, experimental and clinical studies indicate impairments in both humoral and cellular immunity in an animal model of AD as well as in AD patients. On the other hand, anti-inflammatory drugs applied for the treatment of some chronic inflammatory diseases have been shown to reduce risk of AD in these ...patients. Therefore, it seems that anti-inflammatory drugs and other substances which can control the activity of immunocompetent cells and the level of endogenous immune response can be valuable in the treatment of AD patients.

Keywords:
Alzheimer's disease / inflammation / neuroimmunomodulation / therapy
Source:
International Journal of Neuroscience, 1998, 95, 3-4, 203-236
Publisher:
  • Taylor & Francis Ltd, Abingdon

DOI: 10.3109/00207459809003341

ISSN: 0020-7454

PubMed: 9777440

WoS: 000076776300006

Scopus: 2-s2.0-0032167787
[ Google Scholar ]
37
34
URI
http://intor.torlakinstitut.com/handle/123456789/85
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Popović, M.
AU  - Caballero-Bleda, M.
AU  - Puelles, L.
AU  - Popović, N.
AU  - Popović, N.
PY  - 1998
UR  - http://intor.torlakinstitut.com/handle/123456789/85
AB  - The contribution of autoimmune processes or inflammatory components in the etiology and pathogenesis of Alzheimer's disease (AD) has been suspected for many years. The presence of antigen-presenting, HLA-DR-positive and other immunoregulatory cells, components of complement, inflammatory cytokines and acute phase reactants have been established in tissue of AD neuropathology. Although these data do not confirm the immune response as a primary cause of AD, they indicate involvement of immune processes at least as a secondary or tertiary reaction to the preexisting pathogen and point out its driving-force role in AD pathogenesis. These processes may contribute to systemic immune response. Thus, experimental and clinical studies indicate impairments in both humoral and cellular immunity in an animal model of AD as well as in AD patients. On the other hand, anti-inflammatory drugs applied for the treatment of some chronic inflammatory diseases have been shown to reduce risk of AD in these patients. Therefore, it seems that anti-inflammatory drugs and other substances which can control the activity of immunocompetent cells and the level of endogenous immune response can be valuable in the treatment of AD patients.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease
EP  - 236
IS  - 3-4
SP  - 203
VL  - 95
DO  - 10.3109/00207459809003341
UR  - conv_92
ER  - 
@article{
author = "Popović, M. and Caballero-Bleda, M. and Puelles, L. and Popović, N. and Popović, N.",
year = "1998",
abstract = "The contribution of autoimmune processes or inflammatory components in the etiology and pathogenesis of Alzheimer's disease (AD) has been suspected for many years. The presence of antigen-presenting, HLA-DR-positive and other immunoregulatory cells, components of complement, inflammatory cytokines and acute phase reactants have been established in tissue of AD neuropathology. Although these data do not confirm the immune response as a primary cause of AD, they indicate involvement of immune processes at least as a secondary or tertiary reaction to the preexisting pathogen and point out its driving-force role in AD pathogenesis. These processes may contribute to systemic immune response. Thus, experimental and clinical studies indicate impairments in both humoral and cellular immunity in an animal model of AD as well as in AD patients. On the other hand, anti-inflammatory drugs applied for the treatment of some chronic inflammatory diseases have been shown to reduce risk of AD in these patients. Therefore, it seems that anti-inflammatory drugs and other substances which can control the activity of immunocompetent cells and the level of endogenous immune response can be valuable in the treatment of AD patients.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease",
pages = "236-203",
number = "3-4",
volume = "95",
doi = "10.3109/00207459809003341",
url = "conv_92"
}
Popović, M., Caballero-Bleda, M., Puelles, L., Popović, N.,& Popović, N.. (1998). Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 95(3-4), 203-236.
https://doi.org/10.3109/00207459809003341
conv_92
Popović M, Caballero-Bleda M, Puelles L, Popović N, Popović N. Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease. in International Journal of Neuroscience. 1998;95(3-4):203-236.
doi:10.3109/00207459809003341
conv_92 .
Popović, M., Caballero-Bleda, M., Puelles, L., Popović, N., Popović, N., "Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease" in International Journal of Neuroscience, 95, no. 3-4 (1998):203-236,
https://doi.org/10.3109/00207459809003341 .,
conv_92 .

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