Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats
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1998
Članak u časopisu (Objavljena verzija)
Metapodaci
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Our recent studies suggest that lesions of the nucleus basalis magnocellularis (nbm) in rats induce a significant decrease of core body temperature in standard laboratory conditions. Considering the importance of calcium homeostasis in thermoregulation, as well as in the pathogenesis of neurodegeneration, the aim of the present study was to investigate the effect of acute verapamil treatment on body temperature in nbm-lesioned rats. The body temperature was registered before and 30 min after verapamil was subcutaneously administered (1.0, 2.5, 5.0 and 10.0 mg/kg). Verapamil did not change body temperature in control animals. However, verapamil in doses of 2.5 and 5.0 mg/kg significantly increased the core body temperature in nbm-lesioned rats nearly up to the temperature of control animals. Findings that verapamil in doses of 1.0 and 10.0 mg/kg did not change body temperature in nbm-lesioned suggest the existence of an inverted U-shape curve in its effect.
Ključne reči:
Alzheimer's disease / body temperature / nucleus basalis magnocellularis / rats / verapamilIzvor:
Neuroscience Research Communications, 1998, 23, 3, 181-187Izdavač:
- Wiley, Hoboken
DOI: 10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E
ISSN: 0893-6609
WoS: 000077843000006
Scopus: 2-s2.0-0032413385
Institucija/grupa
TorlakTY - JOUR AU - Popović, M. AU - Popović, N. AU - Caballero-Bleda, M. AU - Puelles, L. PY - 1998 UR - http://intor.torlakinstitut.com/handle/123456789/84 AB - Our recent studies suggest that lesions of the nucleus basalis magnocellularis (nbm) in rats induce a significant decrease of core body temperature in standard laboratory conditions. Considering the importance of calcium homeostasis in thermoregulation, as well as in the pathogenesis of neurodegeneration, the aim of the present study was to investigate the effect of acute verapamil treatment on body temperature in nbm-lesioned rats. The body temperature was registered before and 30 min after verapamil was subcutaneously administered (1.0, 2.5, 5.0 and 10.0 mg/kg). Verapamil did not change body temperature in control animals. However, verapamil in doses of 2.5 and 5.0 mg/kg significantly increased the core body temperature in nbm-lesioned rats nearly up to the temperature of control animals. Findings that verapamil in doses of 1.0 and 10.0 mg/kg did not change body temperature in nbm-lesioned suggest the existence of an inverted U-shape curve in its effect. PB - Wiley, Hoboken T2 - Neuroscience Research Communications T1 - Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats EP - 187 IS - 3 SP - 181 VL - 23 DO - 10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E ER -
@article{ author = "Popović, M. and Popović, N. and Caballero-Bleda, M. and Puelles, L.", year = "1998", abstract = "Our recent studies suggest that lesions of the nucleus basalis magnocellularis (nbm) in rats induce a significant decrease of core body temperature in standard laboratory conditions. Considering the importance of calcium homeostasis in thermoregulation, as well as in the pathogenesis of neurodegeneration, the aim of the present study was to investigate the effect of acute verapamil treatment on body temperature in nbm-lesioned rats. The body temperature was registered before and 30 min after verapamil was subcutaneously administered (1.0, 2.5, 5.0 and 10.0 mg/kg). Verapamil did not change body temperature in control animals. However, verapamil in doses of 2.5 and 5.0 mg/kg significantly increased the core body temperature in nbm-lesioned rats nearly up to the temperature of control animals. Findings that verapamil in doses of 1.0 and 10.0 mg/kg did not change body temperature in nbm-lesioned suggest the existence of an inverted U-shape curve in its effect.", publisher = "Wiley, Hoboken", journal = "Neuroscience Research Communications", title = "Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats", pages = "187-181", number = "3", volume = "23", doi = "10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E" }
Popović, M., Popović, N., Caballero-Bleda, M.,& Puelles, L.. (1998). Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats. in Neuroscience Research Communications Wiley, Hoboken., 23(3), 181-187. https://doi.org/10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E
Popović M, Popović N, Caballero-Bleda M, Puelles L. Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats. in Neuroscience Research Communications. 1998;23(3):181-187. doi:10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E .
Popović, M., Popović, N., Caballero-Bleda, M., Puelles, L., "Effect of acute verapamil treatment on body temperature in nucleus basalis magnocellularis-lesioned rats" in Neuroscience Research Communications, 23, no. 3 (1998):181-187, https://doi.org/10.1002/(SICI)1520-6769(199811/12)23:3181::AID-NRC63.0.CO;2-E . .