Приказ основних података о документу
Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat
dc.creator | Popović, M. | |
dc.creator | Jovanova-Nešić, Katica | |
dc.creator | Popović, N. | |
dc.creator | Ugrešić, Nenad | |
dc.creator | Kostić, V. | |
dc.creator | Rakić, L. | |
dc.date.accessioned | 2021-02-18T10:20:23Z | |
dc.date.available | 2021-02-18T10:20:23Z | |
dc.date.issued | 1997 | |
dc.identifier.issn | 0020-7454 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/81 | |
dc.description.abstract | The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Neuroscience | |
dc.subject | nucleus basalis magnocellularis | en |
dc.subject | brain lesions | en |
dc.subject | plaque-forming cell response | en |
dc.subject | Arthus reaction | en |
dc.subject | delayed hypersensitivity | en |
dc.subject | antibody production | en |
dc.subject | rat | en |
dc.title | Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 176 | |
dc.citation.issue | 3-4 | |
dc.citation.other | 89(3-4): 165-176 | |
dc.citation.spage | 165 | |
dc.citation.volume | 89 | |
dc.identifier.doi | 10.3109/00207459708988472 | |
dc.identifier.pmid | 9134454 | |
dc.identifier.scopus | 2-s2.0-0031080273 | |
dc.identifier.wos | A1997WW41100003 | |
dc.type.version | publishedVersion |