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Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat

Authorized Users Only
1997
Authors
Popović, M.
Jovanova-Nešić, Katica
Popović, N.
Ugrešić, Nenad
Kostić, V.
Rakić, L.
Article (Published version)
Metadata
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Abstract
The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.
Keywords:
nucleus basalis magnocellularis / brain lesions / plaque-forming cell response / Arthus reaction / delayed hypersensitivity / antibody production / rat
Source:
International Journal of Neuroscience, 1997, 89, 3-4, 165-176
Publisher:
  • Taylor & Francis Ltd, Abingdon

DOI: 10.3109/00207459708988472

ISSN: 0020-7454

PubMed: 9134454

WoS: A1997WW41100003

Scopus: 2-s2.0-0031080273
[ Google Scholar ]
6
7
URI
http://intor.torlakinstitut.com/handle/123456789/81
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Popović, M.
AU  - Jovanova-Nešić, Katica
AU  - Popović, N.
AU  - Ugrešić, Nenad
AU  - Kostić, V.
AU  - Rakić, L.
PY  - 1997
UR  - http://intor.torlakinstitut.com/handle/123456789/81
AB  - The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat
EP  - 176
IS  - 3-4
SP  - 165
VL  - 89
DO  - 10.3109/00207459708988472
UR  - conv_499
ER  - 
@article{
author = "Popović, M. and Jovanova-Nešić, Katica and Popović, N. and Ugrešić, Nenad and Kostić, V. and Rakić, L.",
year = "1997",
abstract = "The present study was undertaken to elucidate whether electrolytic lesions of nucleus basalis magnocellularis-NBM (an animal model of Alzheimer's disease-AD) may influence humoral and cellular immune responses in adult male Wistar rats. For this purpose intact control (IC), sham-operated (SO) and NBM-lesioned rats were divided into two main groups: (1) rats immunized with sheep red blood cells (SRBC) for plaque-forming cell (PFC) response and anti-SRBC agglutinins, and (2) rats immunized with bovine serum albumin in complete Freund's adjuvant (BSA-CFA) for anti-BSA antibody production, Arthus and delayed hypersensitivity skin reaction to BSA. PFC responses and anti-SRBC agglutinins as well as diameter and expression of edema/induration of Arthus/delayed skin reaction and titer of anti-BSA antibody were significantly lower in NBM lesioned rats (compared to IC and SO). The results showed that in NBM-lesioned rats both the humoral and cellular immune responses were suppressed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat",
pages = "176-165",
number = "3-4",
volume = "89",
doi = "10.3109/00207459708988472",
url = "conv_499"
}
Popović, M., Jovanova-Nešić, K., Popović, N., Ugrešić, N., Kostić, V.,& Rakić, L.. (1997). Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 89(3-4), 165-176.
https://doi.org/10.3109/00207459708988472
conv_499
Popović M, Jovanova-Nešić K, Popović N, Ugrešić N, Kostić V, Rakić L. Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat. in International Journal of Neuroscience. 1997;89(3-4):165-176.
doi:10.3109/00207459708988472
conv_499 .
Popović, M., Jovanova-Nešić, Katica, Popović, N., Ugrešić, Nenad, Kostić, V., Rakić, L., "Humoral and cell-mediated immune responses following lesions of the nucleus basalis magnocellularis in the rat" in International Journal of Neuroscience, 89, no. 3-4 (1997):165-176,
https://doi.org/10.3109/00207459708988472 .,
conv_499 .

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