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dc.creatorPopović, M.
dc.creatorCaballero-Bleda, M.
dc.creatorPopović, N.
dc.creatorBokonjić, D.
dc.creatorDobrić, Silva
dc.date.accessioned2021-02-18T10:19:51Z
dc.date.available2021-02-18T10:19:51Z
dc.date.issued1997
dc.identifier.issn0020-7454
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/74
dc.description.abstractIt is well known that disturbance of calcium homeostasis has a significant role in the development of neurodegenerative disorders, such as Alzheimer's disease (AD). Our recent data suggest that acute treatment with the calcium antagonist verapamil can improve some behavioral deficits in an experimental model of AD. Therefore, the present study was done to establish the effect of chronically administered verapamil on cognitive and noncognitive behavior of rats with bilateral electrolytical lesions of nucleus basalis manocellularis (NBM) - an animal model of AD. The NBM lesions produce a deficit in performance of diverse behavior tests: active avoidance (AA), low level of fear (the open field test) as well as aggressive (the test of foot-shock induced aggression) and depressive (the learned helplessness test) behavior. Verapamil (1.0, 2.5, 5.0 and 10.0 mg/kg i.p.) or saline solution (1 ml/kg i.p.) were injected 24 hr after the lesion of NBM and then repeatedly administered during the next 8 days (twice a day). Performance of the two-way active avoidance test, the open field test, the foot shock-induced aggression test and the learned helplessness test were done on day 4 after the last verapamil or saline treatment (day 13 after the lesion). Verapamil in doses of 2.5 and 5.0 mg/kg significantly ameliorated the deficit in the performance of AA, the open field behavior, and the depression, but not the aggressive behavior. The obtained beneficial effect of chronic administered verapamil suggests that the regulation of calcium homeostasis during the early period after NBM lesions might be a reasonable way to prevent the behavioral deficits in an experimental model of AD.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Neuroscience
dc.subjectAlzheimer's diseaseen
dc.subjectnucleus basalis magnocellularisen
dc.subjecttwo-way active avoidanceen
dc.subjectopen fielden
dc.subjectfoot-shock aggressionen
dc.subjectlearned helplessnessen
dc.subjectchronic verapamil treatmenten
dc.subjectneuroprotection ratsen
dc.titleNeuroprotective effect of chronic verapamil treatment on cognitive and noncognitive deficits in an experimental Alzheimer's disease in ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage93
dc.citation.issue1-2
dc.citation.other92(1-2): 79-93
dc.citation.spage79
dc.citation.volume92
dc.identifier.doi10.3109/00207459708986392
dc.identifier.pmid9522258
dc.identifier.rcubconv_75
dc.identifier.scopus2-s2.0-0031278007
dc.identifier.wos000072203800008
dc.type.versionpublishedVersion


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