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dc.creatorKovačević-Jovanović, Vesna
dc.creatorLaban, Olgica
dc.creatorStanojević, Stanislava
dc.creatorMiletić, Tatjana
dc.creatorDimitrijević, Mirjana
dc.creatorRadulović, Jelena
dc.date.accessioned2021-02-18T10:19:43Z
dc.date.available2021-02-18T10:19:43Z
dc.date.issued1997
dc.identifier.issn1021-7401
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/72
dc.description.abstractThe serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.en
dc.publisherKarger, Basel
dc.rightsrestrictedAccess
dc.sourceNeuroimmunomodulation
dc.subjectantibody productionen
dc.subjectcentral nervous system immunizationen
dc.subjecttraumaen
dc.subjectpolyclonal stimulationen
dc.titleChanges in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the raten
dc.typearticle
dc.rights.licenseARR
dc.citation.epage187
dc.citation.issue4
dc.citation.other4(4): 181-187
dc.citation.spage181
dc.citation.volume4
dc.identifier.doi10.1159/000097336
dc.identifier.pmid9524962
dc.identifier.rcubconv_76
dc.identifier.scopus2-s2.0-13144276364
dc.identifier.wos000072207500002
dc.type.versionpublishedVersion


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