Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat
Само за регистроване кориснике
1997
Аутори
Kovačević-Jovanović, VesnaLaban, Olgica
Stanojević, Stanislava
Miletić, Tatjana
Dimitrijević, Mirjana
Radulović, Jelena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.
Кључне речи:
antibody production / central nervous system immunization / trauma / polyclonal stimulationИзвор:
Neuroimmunomodulation, 1997, 4, 4, 181-187Издавач:
- Karger, Basel
DOI: 10.1159/000097336
ISSN: 1021-7401
PubMed: 9524962
WoS: 000072207500002
Scopus: 2-s2.0-13144276364
Институција/група
TorlakTY - JOUR AU - Kovačević-Jovanović, Vesna AU - Laban, Olgica AU - Stanojević, Stanislava AU - Miletić, Tatjana AU - Dimitrijević, Mirjana AU - Radulović, Jelena PY - 1997 UR - http://intor.torlakinstitut.com/handle/123456789/72 AB - The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response. PB - Karger, Basel T2 - Neuroimmunomodulation T1 - Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat EP - 187 IS - 4 SP - 181 VL - 4 DO - 10.1159/000097336 ER -
@article{ author = "Kovačević-Jovanović, Vesna and Laban, Olgica and Stanojević, Stanislava and Miletić, Tatjana and Dimitrijević, Mirjana and Radulović, Jelena", year = "1997", abstract = "The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.", publisher = "Karger, Basel", journal = "Neuroimmunomodulation", title = "Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat", pages = "187-181", number = "4", volume = "4", doi = "10.1159/000097336" }
Kovačević-Jovanović, V., Laban, O., Stanojević, S., Miletić, T., Dimitrijević, M.,& Radulović, J.. (1997). Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat. in Neuroimmunomodulation Karger, Basel., 4(4), 181-187. https://doi.org/10.1159/000097336
Kovačević-Jovanović V, Laban O, Stanojević S, Miletić T, Dimitrijević M, Radulović J. Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat. in Neuroimmunomodulation. 1997;4(4):181-187. doi:10.1159/000097336 .
Kovačević-Jovanović, Vesna, Laban, Olgica, Stanojević, Stanislava, Miletić, Tatjana, Dimitrijević, Mirjana, Radulović, Jelena, "Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat" in Neuroimmunomodulation, 4, no. 4 (1997):181-187, https://doi.org/10.1159/000097336 . .