The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.
Keywords:
antibody production / central nervous system immunization / trauma / polyclonal stimulation
TY - JOUR
AU - Kovačević-Jovanović, Vesna
AU - Laban, Olgica
AU - Stanojević, Stanislava
AU - Miletić, Tatjana
AU - Dimitrijević, Mirjana
AU - Radulović, Jelena
PY - 1997
UR - http://intor.torlakinstitut.com/handle/123456789/72
AB - The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.
PB - Karger, Basel
T2 - Neuroimmunomodulation
T1 - Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat
EP - 187
IS - 4
SP - 181
VL - 4
DO - 10.1159/000097336
UR - conv_76
ER -
@article{
author = "Kovačević-Jovanović, Vesna and Laban, Olgica and Stanojević, Stanislava and Miletić, Tatjana and Dimitrijević, Mirjana and Radulović, Jelena",
year = "1997",
abstract = "The serum antibody response to ovalbumin (OA) has been investigated following intracerebroventricular (i.c.v.) and intravenous administration of antigen in the rat, under altered neuronal and immunological conditions. I.c.v. administration of antigen was far more potent in eliciting humoral immune response. Central nervous system (CNS) immunization under the conditions of disrupted blood-brain barrier decreased anti-GA antibody production. Peripheral polyclonal stimulation with Bordetella per tussis increased production of specific antibodies to i.c.v. injected antigen, while complete Freund's adjuvant had no effect on the immune response. These results suggest that CNS compartmentalization of antigen may be critical for mounting strong antibody production, and that peripheral polyclonal stimulation of the immune system may markedly contribute to the overall intensity of the immune response.",
publisher = "Karger, Basel",
journal = "Neuroimmunomodulation",
title = "Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat",
pages = "187-181",
number = "4",
volume = "4",
doi = "10.1159/000097336",
url = "conv_76"
}
Kovačević-Jovanović, V., Laban, O., Stanojević, S., Miletić, T., Dimitrijević, M.,& Radulović, J.. (1997). Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat. in Neuroimmunomodulation
Karger, Basel., 4(4), 181-187.
https://doi.org/10.1159/000097336
conv_76
Kovačević-Jovanović V, Laban O, Stanojević S, Miletić T, Dimitrijević M, Radulović J. Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat. in Neuroimmunomodulation. 1997;4(4):181-187.
doi:10.1159/000097336
conv_76 .
Kovačević-Jovanović, Vesna, Laban, Olgica, Stanojević, Stanislava, Miletić, Tatjana, Dimitrijević, Mirjana, Radulović, Jelena, "Changes in immunological and neuronal conditions markedly altered antibody response to intracerebroventricularly injected ovalbumin in the rat" in Neuroimmunomodulation, 4, no. 4 (1997):181-187,
https://doi.org/10.1159/000097336 .,
conv_76 .
