Serologic diagnosis of Crimean hemorrhagic fever in Kosovo and Metohia

Abstract

In the period June-November 1995, 292 sera from 159 patients and 80 healthy persons from Kosovo and Metohia were tested for the presence of antibodies against the causative agents of Crimean hemorrhagic fever (CHF) and hemorrhagic fever with renal syndrome (HFRS). Diffusion precipitation test in agar gel and indirect immunofluorescence assay were used. Specific antibodies against CHF virus were found in 6.9% and against HFRS virus in 15.1 patient's sera. Antibodies against CHF virus were proved in sera of patients on the fifth day from the disease onset at the earliest. No wanted antibodies were found in healthy persons' sera. The results of sera testing on antibodies against CHF virus were analyzed in detail.