Fatty acid profiling in amyotrophic lateral sclerosis
Само за регистроване кориснике
2023
Поглавље у монографији (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, affecting motor neurons, which is characterized by the progressive loss of motor function. Sufficient evidence has been gathered, either in the form of experimental results from animal disease models or from the assessment of affected human subjects, which implicates metabolic changes in the course of ALS. Hypermetabolism, abnormal glucose tolerance and dyslipidaemia were reported to have high incidence in ALS patients. In fact, according to published studies, BMI is significantly and inversely associated with ALS progression. Here, we discuss basic principles of fatty acid metabolism, composition and the existing knowledge of metabolic and fatty acid composition changes in ALS patients. Literature data suggest that ALS patients have unfavorable changes in the fatty acid profile, especially because of the low level of long-chain polyunsaturated fatty acids. Nutritional interventions and supplementation with vario...us foods or food supplements are currently not showing conclusive results, implying there is more to learn about potential ways to modify this illness.
Кључне речи:
Amyotrophic lateral sclerosis / Neurodegeneration / Fatty acids / Polyunsaturated fatty acids / β-oxidationИзвор:
Diet and Nutrition in Neurological Disorders, 2023, 155-172Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
- Ефекти хомоцистеина и хомоцистеину сродних супстанци на кардиоваскуларни систем: Улога гасних трансмитера No, H2S и CO (RS-MESTD-Basic Research (BR or ON)-175043)
- Биомаркери у неуродегенеративним и малигним процесима (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41005)
- Испитивање молекуларно-генетских, патохистолошких и биохемијских карактеристика неуромишићних болести (RS-MESTD-Basic Research (BR or ON)-175083)
DOI: 10.1016/B978-0-323-89834-8.00023-4
ISBN: 978-0-323-89834-8
Scopus: 2-s2.0-85166123814
Институција/група
TorlakTY - CHAP AU - Minić, Rajna AU - Stević, Zorica AU - Arsić, Aleksandra. PY - 2023 UR - http://intor.torlakinstitut.com/handle/123456789/656 AB - Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, affecting motor neurons, which is characterized by the progressive loss of motor function. Sufficient evidence has been gathered, either in the form of experimental results from animal disease models or from the assessment of affected human subjects, which implicates metabolic changes in the course of ALS. Hypermetabolism, abnormal glucose tolerance and dyslipidaemia were reported to have high incidence in ALS patients. In fact, according to published studies, BMI is significantly and inversely associated with ALS progression. Here, we discuss basic principles of fatty acid metabolism, composition and the existing knowledge of metabolic and fatty acid composition changes in ALS patients. Literature data suggest that ALS patients have unfavorable changes in the fatty acid profile, especially because of the low level of long-chain polyunsaturated fatty acids. Nutritional interventions and supplementation with various foods or food supplements are currently not showing conclusive results, implying there is more to learn about potential ways to modify this illness. PB - Elsevier T2 - Diet and Nutrition in Neurological Disorders T1 - Fatty acid profiling in amyotrophic lateral sclerosis EP - 172 SP - 155 DO - 10.1016/B978-0-323-89834-8.00023-4 ER -
@inbook{ author = "Minić, Rajna and Stević, Zorica and Arsić, Aleksandra.", year = "2023", abstract = "Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, affecting motor neurons, which is characterized by the progressive loss of motor function. Sufficient evidence has been gathered, either in the form of experimental results from animal disease models or from the assessment of affected human subjects, which implicates metabolic changes in the course of ALS. Hypermetabolism, abnormal glucose tolerance and dyslipidaemia were reported to have high incidence in ALS patients. In fact, according to published studies, BMI is significantly and inversely associated with ALS progression. Here, we discuss basic principles of fatty acid metabolism, composition and the existing knowledge of metabolic and fatty acid composition changes in ALS patients. Literature data suggest that ALS patients have unfavorable changes in the fatty acid profile, especially because of the low level of long-chain polyunsaturated fatty acids. Nutritional interventions and supplementation with various foods or food supplements are currently not showing conclusive results, implying there is more to learn about potential ways to modify this illness.", publisher = "Elsevier", journal = "Diet and Nutrition in Neurological Disorders", booktitle = "Fatty acid profiling in amyotrophic lateral sclerosis", pages = "172-155", doi = "10.1016/B978-0-323-89834-8.00023-4" }
Minić, R., Stević, Z.,& Arsić, Aleksandra.. (2023). Fatty acid profiling in amyotrophic lateral sclerosis. in Diet and Nutrition in Neurological Disorders Elsevier., 155-172. https://doi.org/10.1016/B978-0-323-89834-8.00023-4
Minić R, Stević Z, Arsić A. Fatty acid profiling in amyotrophic lateral sclerosis. in Diet and Nutrition in Neurological Disorders. 2023;:155-172. doi:10.1016/B978-0-323-89834-8.00023-4 .
Minić, Rajna, Stević, Zorica, Arsić, Aleksandra., "Fatty acid profiling in amyotrophic lateral sclerosis" in Diet and Nutrition in Neurological Disorders (2023):155-172, https://doi.org/10.1016/B978-0-323-89834-8.00023-4 . .