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dc.creatorRadulović, Jelena
dc.creatorMančev, Zorica
dc.creatorStanojević, Stanislava
dc.creatorVasiljević, T.
dc.creatorKovačević-Jovanović, Vesna
dc.creatorPešić, Gordana
dc.date.accessioned2021-02-18T10:19:01Z
dc.date.available2021-02-18T10:19:01Z
dc.date.issued1996
dc.identifier.issn0165-5728
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/63
dc.description.abstractThe effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in-the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 mu g/kg, whereas doses of 20 and 50 mu g/kg exerted immunosuppressive effects. I.c.v. treatment of rats with partial derivative opioid receptor antagonist ICI 174 864 and kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The mu opioid receptor antagonist beta-funaltrexamine (beta-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since beta-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain mu opioid receptors, and suggested a possible involvement of partial derivative and kappa opioid receptors.en
dc.publisherElsevier, Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Neuroimmunology
dc.subjectleucine-enkephalinen
dc.subjectmu opioid receptorsen
dc.subjectdelta opioid receptorsen
dc.subjectkappa opioid receptorsen
dc.subjectplaque-forming cell responseen
dc.subjectcentral nervous systemen
dc.titleModulation of humoral immune response by central administration of leucine-enkephalin: Effects of mu, delta and kappa opioid receptor antagonistsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage161
dc.citation.issue2
dc.citation.other65(2): 155-161
dc.citation.spage155
dc.citation.volume65
dc.identifier.pmid8964897
dc.identifier.rcubconv_491
dc.identifier.wosA1996UU15700008
dc.type.versionpublishedVersion


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