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dc.creatorFrohns, Antonia
dc.creatorStojanović, Marijana
dc.creatorBarisani-Asenbauer, Talin
dc.creatorKuratli, Jasmin
dc.creatorBorel, Nicole
dc.creatorInić-Kanada, Aleksandra
dc.date.accessioned2022-02-22T09:09:25Z
dc.date.available2022-02-22T09:09:25Z
dc.date.issued2021
dc.identifier.issn1011-1344
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/617
dc.description.abstractWater-filtered infrared A and visible light (wIRA/VIS), shown to reduce chlamydial infections in vitro and in vivo, might represent an innovative therapeutic approach against trachoma, a neglected tropical disease caused by ocular infection with the bacterium C. trachomatis. In this in vivo study, we assessed the impact of wIRA radiation in combination with VIS (wavelength range 595–1400 nm, intensity 2100 W/m2) on the retina and cornea in a guinea pig animal model of inclusion conjunctivitis. We investigated the effects 19 days after wIRA/VIS irradiation by comparing a single and double wIRA/VIS treatment with a sham control. By immunolabeling and western blot analyses of critical heat- and stress-responsive proteins, we could not detect wIRA/VIS-induced changes in their expression pattern. Also, immunolabeling of specific retinal marker proteins revealed no changes in their expression pattern caused by the treatment. Our preclinical study suggests wIRA/VIS as a promising and safe therapeutic tool to treat ocular chlamydial infections.
dc.languageen
dc.publisherElsevier
dc.rightsopenAccess
dc.sourceJournal of Photochemistry and Photobiology B: Biology
dc.subjectCornea
dc.subjectguinea pig
dc.subjectRetina
dc.subjectwIRA/VIS
dc.titleEffects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs
dc.typearticleen
dc.rights.licenseBY
dc.citation.spage112306
dc.citation.volume224
dc.identifier.doi10.1016/j.jphotobiol.2021.112306
dc.identifier.scopus2-s2.0-85115741949
dc.identifier.wos000707637900005
dc.type.versionpublishedVersion


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