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dc.creatorZivkovic, Irena
dc.creatorMuhandes, Lina
dc.creatorPetrusic, Vladimir
dc.creatorMinic, Rajna
dc.creatorDimitrijevic, Ljiljana
dc.date.accessioned2021-11-05T14:44:21Z
dc.date.available2021-11-05T14:44:21Z
dc.date.issued2021
dc.identifier.issn0004-1963
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/612
dc.description.abstractNatural, polyreactive, low-affinity antibodies are known to play an important role not only in the immediate defense against pathogens, but also in shaping the acquired immune response. On the other hand, antigen specific, high-affinity antibodies can affect the balance of natural antibodies and lead to autoimmune diseases. In this study we have analyzed the changes that occur in the IgM and IgG pool of natural antibodies after immunization with split or whole virion influenza vaccine. For this purpose, “in-house” developed ELISAs were used. The subjects were divided, according to the vaccination status, into those who had been immunized with the influenza vaccine in previous years and those who had been immunized for the first time. The analysis indicated that the pool of natural antibodies was not impaired by the immunization, evidenced by the lack of changes in any of the groups, and that certain fluctuations were induced in order to maintain the homeostasis of the immune system.sr
dc.language.isoensr
dc.publisherPharmaceutical Association of Serbiasr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200177/RS//sr
dc.rightsopenAccesssr
dc.sourceArhiv za farmacijusr
dc.subjectnatural antibodiessr
dc.subjectimmunizationsr
dc.subjectimmune homeostasissr
dc.titleThe effect of influenza vaccine immunization on natural antibodiessr
dc.typearticlesr
dc.rights.licenseBY-SAsr
dc.citation.epage223
dc.citation.rankM51
dc.citation.spage207
dc.citation.volume71
dc.identifier.doi10.5937/arhfarm71‐31544
dc.type.versionpublishedVersionsr


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