The effect of influenza vaccine immunization on natural antibodies
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Natural, polyreactive, low-affinity antibodies are known to play an important role not only
in the immediate defense against pathogens, but also in shaping the acquired immune response.
On the other hand, antigen specific, high-affinity antibodies can affect the balance of natural
antibodies and lead to autoimmune diseases. In this study we have analyzed the changes that occur
in the IgM and IgG pool of natural antibodies after immunization with split or whole virion
influenza vaccine. For this purpose, “in-house” developed ELISAs were used. The subjects were
divided, according to the vaccination status, into those who had been immunized with the
influenza vaccine in previous years and those who had been immunized for the first time. The
analysis indicated that the pool of natural antibodies was not impaired by the immunization,
evidenced by the lack of changes in any of the groups, and that certain fluctuations were induced
in order to maintain the homeostasis of the immune ...system.
Keywords:
natural antibodies / immunization / immune homeostasisSource:
Arhiv za farmaciju, 2021, 71, 207-223Publisher:
- Pharmaceutical Association of Serbia
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200177 (Immunology Research Centre 'Branislav Janković' Torlak, Belgrade) (RS-MESTD-inst-2020-200177)
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TorlakTY - JOUR AU - Zivkovic, Irena AU - Muhandes, Lina AU - Petrusic, Vladimir AU - Minić, Rajna AU - Dimitrijevic, Ljiljana PY - 2021 UR - http://intor.torlakinstitut.com/handle/123456789/612 AB - Natural, polyreactive, low-affinity antibodies are known to play an important role not only in the immediate defense against pathogens, but also in shaping the acquired immune response. On the other hand, antigen specific, high-affinity antibodies can affect the balance of natural antibodies and lead to autoimmune diseases. In this study we have analyzed the changes that occur in the IgM and IgG pool of natural antibodies after immunization with split or whole virion influenza vaccine. For this purpose, “in-house” developed ELISAs were used. The subjects were divided, according to the vaccination status, into those who had been immunized with the influenza vaccine in previous years and those who had been immunized for the first time. The analysis indicated that the pool of natural antibodies was not impaired by the immunization, evidenced by the lack of changes in any of the groups, and that certain fluctuations were induced in order to maintain the homeostasis of the immune system. PB - Pharmaceutical Association of Serbia T2 - Arhiv za farmaciju T1 - The effect of influenza vaccine immunization on natural antibodies EP - 223 SP - 207 VL - 71 DO - 10.5937/arhfarm71‐31544 ER -
@article{ author = "Zivkovic, Irena and Muhandes, Lina and Petrusic, Vladimir and Minić, Rajna and Dimitrijevic, Ljiljana", year = "2021", abstract = "Natural, polyreactive, low-affinity antibodies are known to play an important role not only in the immediate defense against pathogens, but also in shaping the acquired immune response. On the other hand, antigen specific, high-affinity antibodies can affect the balance of natural antibodies and lead to autoimmune diseases. In this study we have analyzed the changes that occur in the IgM and IgG pool of natural antibodies after immunization with split or whole virion influenza vaccine. For this purpose, “in-house” developed ELISAs were used. The subjects were divided, according to the vaccination status, into those who had been immunized with the influenza vaccine in previous years and those who had been immunized for the first time. The analysis indicated that the pool of natural antibodies was not impaired by the immunization, evidenced by the lack of changes in any of the groups, and that certain fluctuations were induced in order to maintain the homeostasis of the immune system.", publisher = "Pharmaceutical Association of Serbia", journal = "Arhiv za farmaciju", title = "The effect of influenza vaccine immunization on natural antibodies", pages = "223-207", volume = "71", doi = "10.5937/arhfarm71‐31544" }
Zivkovic, I., Muhandes, L., Petrusic, V., Minić, R.,& Dimitrijevic, L.. (2021). The effect of influenza vaccine immunization on natural antibodies. in Arhiv za farmaciju Pharmaceutical Association of Serbia., 71, 207-223. https://doi.org/10.5937/arhfarm71‐31544
Zivkovic I, Muhandes L, Petrusic V, Minić R, Dimitrijevic L. The effect of influenza vaccine immunization on natural antibodies. in Arhiv za farmaciju. 2021;71:207-223. doi:10.5937/arhfarm71‐31544 .
Zivkovic, Irena, Muhandes, Lina, Petrusic, Vladimir, Minić, Rajna, Dimitrijevic, Ljiljana, "The effect of influenza vaccine immunization on natural antibodies" in Arhiv za farmaciju, 71 (2021):207-223, https://doi.org/10.5937/arhfarm71‐31544 . .