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Effect of Met-enkephalin and opioid antagonists on rat macrophages

dc.creatorRadulović, Jelena
dc.creatorDimitrijević, Mirjana
dc.creatorLaban, Olgica
dc.creatorStanojević, Stanislava
dc.creatorVasiljević, T.
dc.creatorKovačević-Jovanović, Vesna
dc.creatorMarković, B.M.
dc.date.accessioned2021-02-18T10:18:46Z
dc.date.available2021-02-18T10:18:46Z
dc.date.issued1995
dc.identifier.issn0196-9781
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/59
dc.description.abstractEffects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.en
dc.relationThis work was supportedb y the Ministry of Science and Technology of the Republic of Serbia. We thank Zuzana Holubek for technical assistance.
dc.rightsrestrictedAccess
dc.sourcePeptides
dc.subjectAO ratsen
dc.subjectDA ratsen
dc.subjectH2O2 releaseen
dc.subjectMet-enkephalinen
dc.subjectOpioid antagonistsen
dc.subjectRat peritoneal macrophagesen
dc.titleEffect of Met-enkephalin and opioid antagonists on rat macrophagesen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1213
dc.citation.issue7
dc.citation.other16(7): 1209-1213
dc.citation.spage1209
dc.citation.volume16
dc.identifier.doi10.1016/0196-9781(95)02003-F
dc.identifier.pmid8545240
dc.identifier.scopus2-s2.0-0028867675
dc.type.versionpublishedVersion


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