The therapeutic effects of human leucocytic interferon-α (IFN) on viral myocarditis and dilative cardiomyopathy (IDC) were investigated interferon-α in a dose of 3 million U/m body surface area daily for 4 weeks was administered i.m. to 7 patients, while 44 patients were treated with conventional therapy alone. During the 7-year follow-up period, initially depressed cardiac function normalized in patients treated with IFN, while it improved insignificantly in conventionally treated patients. Five patients on conventional therapy alone died during the follow-up period compared to one patient treated with interferon-α. No significant side effects attributable to interferon-α were observed during the study. According to several studies enterovirus genomes are found in about 25% of endomyocardial biopsies in patients with myocarditis and IDC, so that double-blind randomized trials to evaluate the therapeutic effects of IFN in this subgroup of patients are warranted.
Keywords:
Cardiomyopathy / Congestive / Interferon type I / Myocarditis / Virus diseases
TY - CONF
AU - Mirić, M.
AU - Brkić, S.
AU - Keserović, N.
PY - 1994
UR - http://intor.torlakinstitut.com/handle/123456789/56
AB - The therapeutic effects of human leucocytic interferon-α (IFN) on viral myocarditis and dilative cardiomyopathy (IDC) were investigated interferon-α in a dose of 3 million U/m body surface area daily for 4 weeks was administered i.m. to 7 patients, while 44 patients were treated with conventional therapy alone. During the 7-year follow-up period, initially depressed cardiac function normalized in patients treated with IFN, while it improved insignificantly in conventionally treated patients. Five patients on conventional therapy alone died during the follow-up period compared to one patient treated with interferon-α. No significant side effects attributable to interferon-α were observed during the study. According to several studies enterovirus genomes are found in about 25% of endomyocardial biopsies in patients with myocarditis and IDC, so that double-blind randomized trials to evaluate the therapeutic effects of IFN in this subgroup of patients are warranted.
PB - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
C3 - Vojnosanitetski Pregled
T1 - Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?
EP - 97
IS - 4 SUPPL.
SP - 93
VL - 51
ER -
@conference{
author = "Mirić, M. and Brkić, S. and Keserović, N.",
year = "1994",
url = "http://intor.torlakinstitut.com/handle/123456789/56",
abstract = "The therapeutic effects of human leucocytic interferon-α (IFN) on viral myocarditis and dilative cardiomyopathy (IDC) were investigated interferon-α in a dose of 3 million U/m body surface area daily for 4 weeks was administered i.m. to 7 patients, while 44 patients were treated with conventional therapy alone. During the 7-year follow-up period, initially depressed cardiac function normalized in patients treated with IFN, while it improved insignificantly in conventionally treated patients. Five patients on conventional therapy alone died during the follow-up period compared to one patient treated with interferon-α. No significant side effects attributable to interferon-α were observed during the study. According to several studies enterovirus genomes are found in about 25% of endomyocardial biopsies in patients with myocarditis and IDC, so that double-blind randomized trials to evaluate the therapeutic effects of IFN in this subgroup of patients are warranted.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski Pregled",
title = "Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?",
pages = "97-93",
number = "4 SUPPL.",
volume = "51"
}
Mirić, M., Brkić, S.,& Keserović, N. (1994). Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?.
Vojnosanitetski Pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 51(4 SUPPL.), 93-97.
Mirić M, Brkić S, Keserović N. Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?. Vojnosanitetski Pregled. 1994;51(4 SUPPL.):93-97
Mirić M., Brkić S., Keserović N., "Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?" Vojnosanitetski Pregled, 51, no. 4 SUPPL. (1994):93-97
