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Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?

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Authors
Mirić, M.
Brkić, S.
Keserović, N.
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Abstract
The therapeutic effects of human leucocytic interferon-α (IFN) on viral myocarditis and dilative cardiomyopathy (IDC) were investigated interferon-α in a dose of 3 million U/m body surface area daily for 4 weeks was administered i.m. to 7 patients, while 44 patients were treated with conventional therapy alone. During the 7-year follow-up period, initially depressed cardiac function normalized in patients treated with IFN, while it improved insignificantly in conventionally treated patients. Five patients on conventional therapy alone died during the follow-up period compared to one patient treated with interferon-α. No significant side effects attributable to interferon-α were observed during the study. According to several studies enterovirus genomes are found in about 25% of endomyocardial biopsies in patients with myocarditis and IDC, so that double-blind randomized trials to evaluate the therapeutic effects of IFN in this subgroup of patients are warranted.
Keywords:
Cardiomyopathy / Congestive / Interferon type I / Myocarditis / Virus diseases
Source:
Vojnosanitetski Pregled, 1994, 51, 4 SUPPL., 93-97
Publisher:
  • Vojnomedicinska akademija - Institut za naučne informacije, Beograd

ISSN: 0042-8450

Scopus: 2-s2.0-0028564997
[ Google Scholar ]
URI
http://intor.torlakinstitut.com/handle/123456789/56
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - CONF
AU  - Mirić, M.
AU  - Brkić, S.
AU  - Keserović, N.
PY  - 1994
UR  - http://intor.torlakinstitut.com/handle/123456789/56
AB  - The therapeutic effects of human leucocytic interferon-α (IFN) on viral myocarditis and dilative cardiomyopathy (IDC) were investigated interferon-α in a dose of 3 million U/m body surface area daily for 4 weeks was administered i.m. to 7 patients, while 44 patients were treated with conventional therapy alone. During the 7-year follow-up period, initially depressed cardiac function normalized in patients treated with IFN, while it improved insignificantly in conventionally treated patients. Five patients on conventional therapy alone died during the follow-up period compared to one patient treated with interferon-α. No significant side effects attributable to interferon-α were observed during the study. According to several studies enterovirus genomes are found in about 25% of endomyocardial biopsies in patients with myocarditis and IDC, so that double-blind randomized trials to evaluate the therapeutic effects of IFN in this subgroup of patients are warranted.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
C3  - Vojnosanitetski Pregled
T1  - Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?
EP  - 97
IS  - 4 SUPPL.
SP  - 93
VL  - 51
UR  - conv_601
ER  - 
@conference{
author = "Mirić, M. and Brkić, S. and Keserović, N.",
year = "1994",
abstract = "The therapeutic effects of human leucocytic interferon-α (IFN) on viral myocarditis and dilative cardiomyopathy (IDC) were investigated interferon-α in a dose of 3 million U/m body surface area daily for 4 weeks was administered i.m. to 7 patients, while 44 patients were treated with conventional therapy alone. During the 7-year follow-up period, initially depressed cardiac function normalized in patients treated with IFN, while it improved insignificantly in conventionally treated patients. Five patients on conventional therapy alone died during the follow-up period compared to one patient treated with interferon-α. No significant side effects attributable to interferon-α were observed during the study. According to several studies enterovirus genomes are found in about 25% of endomyocardial biopsies in patients with myocarditis and IDC, so that double-blind randomized trials to evaluate the therapeutic effects of IFN in this subgroup of patients are warranted.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski Pregled",
title = "Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?",
pages = "97-93",
number = "4 SUPPL.",
volume = "51",
url = "conv_601"
}
Mirić, M., Brkić, S.,& Keserović, N.. (1994). Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?. in Vojnosanitetski Pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 51(4 SUPPL.), 93-97.
conv_601
Mirić M, Brkić S, Keserović N. Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?. in Vojnosanitetski Pregled. 1994;51(4 SUPPL.):93-97.
conv_601 .
Mirić, M., Brkić, S., Keserović, N., "Interferon-alpha: Elective therapy in viral myocarditis and idiopathic dilative cardiomyopathy?" in Vojnosanitetski Pregled, 51, no. 4 SUPPL. (1994):93-97,
conv_601 .

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