Belgrade and Hantaan hantaviruses - the causative agents of severe haemorrhagic fever with renal syndrome in children in Serbia
Abstract
During an outbreak of haemorrhagic fever with renal syndrome (HFRS) in 1989, five children (3 girls, 2 boys, aged 6.8-16 years) with a severe form of the disease were treated; four of these were followed for 22-28 months. The main clinical features in all five patients were: fever, headache, myalgia, abdominal and back pain and vomiting; haemorrhagic syndrome was present in four children. Renal syndrome presented with severe acute renal failure in all five patients. All patients recovered. Serological confirmation by an indirect immunofluorescence assay, by enzyme immunoassay for IgM antibodies and by plaque reduction neutralization test showed infection by Belgrade virus in three and by Hantaan virus in two patients. It was not possible to differentiate these two serogroups on the basis of clinical features. This study provides futher information on the circulation of different hantaviruses causing severe HFRS in Serbia.
Keywords:
Acute renal failure / Belgrade and Hantaan hantaviruses / Haemorrhagic feverSource:
Pediatric Nephrology, 1994, 8, 3, 299-303Publisher:
- Springer-Verlag
DOI: 10.1007/BF00866341
ISSN: 0931-041X
PubMed: 7917855
Scopus: 2-s2.0-0028217918
Collections
Institution/Community
TorlakTY - JOUR AU - Bogdanović, R. AU - Gligić, Ana AU - Nikolić, V. AU - Ognjanović, M. AU - Marković, M. AU - Sarjanović, L. PY - 1994 UR - http://intor.torlakinstitut.com/handle/123456789/55 AB - During an outbreak of haemorrhagic fever with renal syndrome (HFRS) in 1989, five children (3 girls, 2 boys, aged 6.8-16 years) with a severe form of the disease were treated; four of these were followed for 22-28 months. The main clinical features in all five patients were: fever, headache, myalgia, abdominal and back pain and vomiting; haemorrhagic syndrome was present in four children. Renal syndrome presented with severe acute renal failure in all five patients. All patients recovered. Serological confirmation by an indirect immunofluorescence assay, by enzyme immunoassay for IgM antibodies and by plaque reduction neutralization test showed infection by Belgrade virus in three and by Hantaan virus in two patients. It was not possible to differentiate these two serogroups on the basis of clinical features. This study provides futher information on the circulation of different hantaviruses causing severe HFRS in Serbia. PB - Springer-Verlag T2 - Pediatric Nephrology T1 - Belgrade and Hantaan hantaviruses - the causative agents of severe haemorrhagic fever with renal syndrome in children in Serbia EP - 303 IS - 3 SP - 299 VL - 8 DO - 10.1007/BF00866341 ER -
@article{ author = "Bogdanović, R. and Gligić, Ana and Nikolić, V. and Ognjanović, M. and Marković, M. and Sarjanović, L.", year = "1994", abstract = "During an outbreak of haemorrhagic fever with renal syndrome (HFRS) in 1989, five children (3 girls, 2 boys, aged 6.8-16 years) with a severe form of the disease were treated; four of these were followed for 22-28 months. The main clinical features in all five patients were: fever, headache, myalgia, abdominal and back pain and vomiting; haemorrhagic syndrome was present in four children. Renal syndrome presented with severe acute renal failure in all five patients. All patients recovered. Serological confirmation by an indirect immunofluorescence assay, by enzyme immunoassay for IgM antibodies and by plaque reduction neutralization test showed infection by Belgrade virus in three and by Hantaan virus in two patients. It was not possible to differentiate these two serogroups on the basis of clinical features. This study provides futher information on the circulation of different hantaviruses causing severe HFRS in Serbia.", publisher = "Springer-Verlag", journal = "Pediatric Nephrology", title = "Belgrade and Hantaan hantaviruses - the causative agents of severe haemorrhagic fever with renal syndrome in children in Serbia", pages = "303-299", number = "3", volume = "8", doi = "10.1007/BF00866341" }
Bogdanović, R., Gligić, A., Nikolić, V., Ognjanović, M., Marković, M.,& Sarjanović, L.. (1994). Belgrade and Hantaan hantaviruses - the causative agents of severe haemorrhagic fever with renal syndrome in children in Serbia. in Pediatric Nephrology Springer-Verlag., 8(3), 299-303. https://doi.org/10.1007/BF00866341
Bogdanović R, Gligić A, Nikolić V, Ognjanović M, Marković M, Sarjanović L. Belgrade and Hantaan hantaviruses - the causative agents of severe haemorrhagic fever with renal syndrome in children in Serbia. in Pediatric Nephrology. 1994;8(3):299-303. doi:10.1007/BF00866341 .
Bogdanović, R., Gligić, Ana, Nikolić, V., Ognjanović, M., Marković, M., Sarjanović, L., "Belgrade and Hantaan hantaviruses - the causative agents of severe haemorrhagic fever with renal syndrome in children in Serbia" in Pediatric Nephrology, 8, no. 3 (1994):299-303, https://doi.org/10.1007/BF00866341 . .