Show simple item record

dc.creatorDimitrijević, Mirjana
dc.creatorArsenović-Ranin, Nevena
dc.creatorKosec, Duško
dc.creatorBufan, Biljana
dc.creatorNacka-Aleksić, Mirjana
dc.creatorPilipović, Ivan
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:52:59Z
dc.date.available2021-02-18T10:52:59Z
dc.date.issued2020
dc.identifier.issn2045-2322
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/554
dc.description.abstractThe study examined germinal centre (GC) reaction in lymph nodes draining inflamed joints and adjacent tissues (dLNs) in male and female Dark Agouti rat collagen type II (CII)-induced arthritis (CIA) model of rheumatoid arthritis. Female rats exhibiting the greater susceptibility to CIA mounted stronger serum CII-specific IgG response than their male counterparts. This correlated with the higher frequency of GC B cells in female compared with male dLNs. Consistently, the frequency of activated/proliferating Ki-67+ cells among dLN B cells was higher in females than in males. This correlated with the shift in dLN T follicular regulatory (Tfr)/T follicular helper (Tfh) cell ratio towards Tfh cells in females, and greater densities of CD40L and CD40 on their dLN T and B cells, respectively. The higher Tfh cell frequency in females was consistent with the greater dLN expression of mRNA for IL-21/27, the key cytokines involved in Tfh cell generation and their help to B cells. Additionally, in CII-stimulated female rat dLN cell cultures IFN-gamma /IL-4 production ratio was shifted towards IFN-gamma. Consistently, the serum IgG2a(b)/IgG1 CII-specific antibody ratio was shifted towards an IgG2a(b) response in females. Thus, targeting T-/B-cell interactions should be considered in putative further sex-based translational pharmacology research.en
dc.publisherNature Publishing Group, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScientific Reports
dc.titleSex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritisen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue1
dc.citation.other10(1)
dc.citation.rankM21~
dc.citation.volume10
dc.identifier.doi10.1038/s41598-020-58127-y
dc.identifier.fulltexthttp://intor.torlakinstitut.com/bitstream/id/367/551.pdf
dc.identifier.pmid31988383
dc.identifier.rcubconv_478
dc.identifier.scopus2-s2.0-85078337543
dc.identifier.wos000559995900005
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record