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dc.creatorStojanović, Marijana
dc.creatorLukić, Ivana
dc.creatorMarinković, Emilija
dc.creatorKovačević, Ana
dc.creatorMiljković, Radmila
dc.creatorTobias, Joshua
dc.creatorSchabussova, Irma
dc.creatorZlatović, Mario
dc.creatorBarisani-Asenbauer, Talin
dc.creatorWiedermann, Ursula
dc.creatorInić-Kanada, Aleksandra
dc.date.accessioned2021-02-18T10:52:49Z
dc.date.available2021-02-18T10:52:49Z
dc.date.issued2020
dc.identifier.issn2076-393X
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/552
dc.description.abstractVaccines can have heterologous effects on the immune system, i.e., effects other than triggering an immune response against the disease targeted by the vaccine. We investigated whether monoclonal antibodies (mAbs) specific for tetanus could cross-react with Chlamydia and confer heterologous protection against chlamydial infection. The capability of two tetanus-specific mAbs, namely mAb26 and mAb51, to prevent chlamydial infection has been assessed: (i) in vitro, by performing a neutralization assay using human conjunctival epithelial (HCjE) cells infected with Chlamydia trachomatis serovar B, and (ii) in vivo, by using a guinea pig model of Chlamydia caviae-induced inclusion conjunctivitis. The mAb26 has been superior in comparison with mAb51 in the prevention of chlamydial infection in HCjE cells. The mAb26 has conferred approximate to 40% inhibition of the infection, compared to less than 5% inhibition in the presence of the mAb51. In vivo, mAb26 significantly diminished ocular pathology intensity in guinea pigs infected with C. caviae compared to either the mAb51-treated or sham-treated guinea pigs. Our data provide insights that tetanus immunization generates antibodies which induce heterologous chlamydial immunity and promote protection beyond the intended target pathogen.en
dc.publisherMDPI, Basel
dc.relationInstitute for Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Austria
dc.relationLaura Bassi Centers of Expertise (FFG) [822768] - Austrian Research Promotion Agency
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200177/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS//
dc.rightsopenAccess
dc.sourceVaccines
dc.subjectvaccinationen
dc.subjectheterologous immunityen
dc.subjectantibodiesen
dc.subjecttetanusen
dc.subjectChlamydiaen
dc.subjectcross-reactivityen
dc.titleCross-Reactive Effects of Vaccines: Heterologous Immunity between Tetanus and Chlamydiaen
dc.typearticle
dc.rights.licenseARR
dc.citation.issue4
dc.citation.other8(4): 719
dc.citation.rankM21
dc.citation.spage719
dc.citation.volume8
dc.identifier.doi10.3390/vaccines8040719
dc.identifier.fulltexthttp://intor.torlakinstitut.com/bitstream/id/365/549.pdf
dc.identifier.pmid33271962
dc.identifier.rcubconv_488
dc.identifier.scopus2-s2.0-85097255732
dc.identifier.wos000601709900001
dc.type.versionpublishedVersion


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