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dc.creatorMichalickova, Danica
dc.creatorMinić, Rajna
dc.creatorKotur-Stevuljević, Jelena
dc.creatorAnđelković, Marija
dc.creatorDikić, Nenad
dc.creatorKostić-Vučićević, Marija
dc.creatorSlanar, Ondrej
dc.creatorĐorđević, Brižita
dc.date.accessioned2021-02-18T10:52:20Z
dc.date.available2021-02-18T10:52:20Z
dc.date.issued2020
dc.identifier.issn1064-8011
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/545
dc.description.abstractMichalickova, D, Minic, R, Kotur-Stevuljevic, J, Andjelkovic, M, Dikic, N, Kostic-Vucicevic, M, Slanar, O, and Djordjevic, B. Changes in parameters of oxidative stress, immunity, and behavior in endurance athletes during a preparation period in winter.J Strength Cond Res34(10): 2965-2973, 2020-The current study monitored markers of immunological and oxidative status in 9 male elite endurance athletes: V?o(2)max: 68 +/- 11 ml center dot kg(-1)center dot min(-1), age: 24 +/- 2.5 years, and training loads: 128 +/- 21 metabolic equivalents-h center dot wk(-1)during a 3-month preparation period in winter (January-March). Self-rated state of moods evaluation (by Profile of Mood States questionnaire) was performed, and blood samples were collected at the beginning and end of the study. Spectrophotometric methods and enzyme-linked immunosorbent assay were used for parameters' determination. The level of concanavalin A (ConA)-stimulated interferon-gamma (IFN-gamma) from peripheral blood mononuclear cells (PBMCs) was increased (562 [147-852] vs. 1,097 [451-1842] pg center dot ml(-1),p= 0.013). Also, the level of transforming growth factor-1 (TGF-beta 1) in serum was elevated (2.5 [1.4-5.1] vs. 7.2 [4.9-8.2] ng center dot ml(-1),p= 0.015). There was no change in the level of peptidoglycan (PGN)-stimulated interleukin (IL)-10 from PBMCs. There were no significant changes in PBMCs proliferation/viability on stimulation with ConA and PGN during the study. No changes in superoxide dismutase, prooxidative-antioxidative balance, total oxidant status (TOS), and thiobarbituric acid reactive substances were observed along the study. Total antioxidant status (TAS) was increased (910 +/- 174 vs. 1,090 +/- 102 mu mol center dot L-1,p= 0.018), and activity of paraoxonase (PON1) was decreased (523 +/- 295 vs. 335 +/- 183 U center dot L-1,p= 0.003) at the end of the study. Advanced oxidation protein products were increased (25 +/- 7.9 vs. 42 +/- 7.6 mu mol center dot L-1,p= 0.011). The self-rated sense of vigor significantly declined (20 +/- 2.1 vs. 14 +/- 3.4,p= 0.045). In conclusion, 3 months of regular training in winter induced prominent changes in cytokines, biomarkers of oxidative stress, and antioxidative enzyme activity. These changes might increase susceptibility of athletes to disease and muscle damage and consequently lead to performance reduction.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.relationCharles University Project Progress Q25
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Strength and Conditioning Research
dc.subjectcytokinesen
dc.subjectsalivary IgA antibodiesen
dc.subjectPOMSen
dc.titleChanges in Parameters of Oxidative Stress, Immunity, and Behavior in Endurance Athletes During a Preparation Period in Winteren
dc.typearticle
dc.rights.licenseARR
dc.citation.epage2973
dc.citation.issue10
dc.citation.other34(10): 2965-2973
dc.citation.rankM21
dc.citation.spage2965
dc.citation.volume34
dc.identifier.doi10.1519/JSC.0000000000002780
dc.identifier.pmid30199454
dc.identifier.scopus2-s2.0-85071996741
dc.identifier.wos000575992200033
dc.type.versionpublishedVersion


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