Приказ основних података о документу
Propranolol Impairs Primary Immune Responses in Rat Experimental Autoimmune Encephalomyelitis
dc.creator | Pilipović, Ivan | |
dc.creator | Vujnović, Ivana | |
dc.creator | Petrović, Raisa | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2021-02-18T10:52:03Z | |
dc.date.available | 2021-02-18T10:52:03Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1021-7401 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/541 | |
dc.description.abstract | Objective: We examined the effect of beta-adrenoceptor (AR) blockade in the preclinical phase of experimental autoimmune encephalomyelitis (EAE), the most commonly used model of multiple sclerosis, on the development of primary CD4+ T-cell responses in draining lymph nodes (dLNs). Methods: CD11b+ cell migration to dLNs, CD4+ T-cell activation/proliferation, and IL-17+ CD4+ (Th17) cell numbers in dLN and spinal cord (SC) were examined in male and female Dark Agouti rats using flow cytometry analysis. Results: Irrespective of sex, in propranolol-treated (PT) rats, migration of CD11b+ antigen-presenting cells from the site of immunization to dLNs was impaired compared with saline-treated controls and consequently the frequency of all CD11b+ cells in dLNs and activated cells among them, too. This correlated with decreased expression of CCL19/21 transcripts in dLNs. Consistently, the frequency of activated/proliferating cells among dLN CD4+ T cells was reduced in PT rats. Additionally, propranolol reduced the number of Th17 cells in dLNs and SC. Consistently, male and female PT rats exhibited a decreased incidence of EAE and prolonged duration of the asymptomatic disease phase. Conclusion: This study suggests that sympathetic dysregulation is involved in the outbreak of clinical EAE. (C) 2019 S. Karger AG, Basel | en |
dc.publisher | Karger, Basel | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Neuroimmunomodulation | |
dc.subject | Experimental autoimmune encephalomyelitis | en |
dc.subject | Th17 lymphocytes | en |
dc.subject | Antigen-presenting cell migration | en |
dc.subject | beta-Adrenoceptor | en |
dc.subject | CCL19 | en |
dc.subject | CCL21 | en |
dc.title | Propranolol Impairs Primary Immune Responses in Rat Experimental Autoimmune Encephalomyelitis | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 138 | |
dc.citation.issue | 3 | |
dc.citation.other | 26(3): 129-138 | |
dc.citation.rank | M23 | |
dc.citation.spage | 129 | |
dc.citation.volume | 26 | |
dc.identifier.doi | 10.1159/000500094 | |
dc.identifier.pmid | 31132768 | |
dc.identifier.scopus | 2-s2.0-85066936523 | |
dc.identifier.wos | 000481456200003 | |
dc.type.version | publishedVersion |