Приказ основних података о документу

dc.creatorPilipović, Ivan
dc.creatorVujnović, Ivana
dc.creatorPetrović, Raisa
dc.creatorStojić-Vukanić, Zorica
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:52:03Z
dc.date.available2021-02-18T10:52:03Z
dc.date.issued2019
dc.identifier.issn1021-7401
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/541
dc.description.abstractObjective: We examined the effect of beta-adrenoceptor (AR) blockade in the preclinical phase of experimental autoimmune encephalomyelitis (EAE), the most commonly used model of multiple sclerosis, on the development of primary CD4+ T-cell responses in draining lymph nodes (dLNs). Methods: CD11b+ cell migration to dLNs, CD4+ T-cell activation/proliferation, and IL-17+ CD4+ (Th17) cell numbers in dLN and spinal cord (SC) were examined in male and female Dark Agouti rats using flow cytometry analysis. Results: Irrespective of sex, in propranolol-treated (PT) rats, migration of CD11b+ antigen-presenting cells from the site of immunization to dLNs was impaired compared with saline-treated controls and consequently the frequency of all CD11b+ cells in dLNs and activated cells among them, too. This correlated with decreased expression of CCL19/21 transcripts in dLNs. Consistently, the frequency of activated/proliferating cells among dLN CD4+ T cells was reduced in PT rats. Additionally, propranolol reduced the number of Th17 cells in dLNs and SC. Consistently, male and female PT rats exhibited a decreased incidence of EAE and prolonged duration of the asymptomatic disease phase. Conclusion: This study suggests that sympathetic dysregulation is involved in the outbreak of clinical EAE. (C) 2019 S. Karger AG, Baselen
dc.publisherKarger, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceNeuroimmunomodulation
dc.subjectExperimental autoimmune encephalomyelitisen
dc.subjectTh17 lymphocytesen
dc.subjectAntigen-presenting cell migrationen
dc.subjectbeta-Adrenoceptoren
dc.subjectCCL19en
dc.subjectCCL21en
dc.titlePropranolol Impairs Primary Immune Responses in Rat Experimental Autoimmune Encephalomyelitisen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage138
dc.citation.issue3
dc.citation.other26(3): 129-138
dc.citation.rankM23
dc.citation.spage129
dc.citation.volume26
dc.identifier.doi10.1159/000500094
dc.identifier.pmid31132768
dc.identifier.scopus2-s2.0-85066936523
dc.identifier.wos000481456200003
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу