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dc.creatorŽivković, Irena
dc.creatorPetrović, Raisa
dc.creatorArsenović-Ranin, Nevena
dc.creatorPetrušić, Vladimir
dc.creatorMinić, Rajna
dc.creatorBufan, Biljana
dc.creatorPopović, Olga
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:50:44Z
dc.date.available2021-02-18T10:50:44Z
dc.date.issued2018
dc.identifier.issn1045-1056
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/522
dc.description.abstractThe study explored influence of biological sex on development of humoral immune response to seasonal trivalent whole inactivated virus (WIV) and split virus (SV) influenza vaccines in outbred Swiss mouse model. To this end, mice of both sexes were immunized with WIV (WIV mice) and SV vaccines (SV mice) and examined for specific antibody response. Irrespective of sex, total IgG and neutralizing antibody responses to distinct virus strains were weaker in SV than in WIV mice. In WIV mice of both sexes, irrespective of strain specificity, IgG isotype response was dominated by IgG2a antibodies, while in SV mice nearly equal representation of IgG2a and IgG1 antibodies was found. The analyses of sex differences showed higher titers of H1N1-specific and both H1N1- and H3N2-specific total IgG and neutralizing antibodies in female WIV and SV mice, respectively. Additionally, sexual dimorphism in IgG subclass profile depended on vaccine type. Specifically, compared with males, in females WIV shifted IgG2a/IgG1 antibody ratio towards IgG2a isotype on the account of weaker IgG1 response, whereas in SV mice, irrespective of virus strain, IgG2a and IgG1 isotypes were equally represented in both sexes. These findings indicate the vaccine type-dependent sex bias in antibody response to inactivated influenza vaccines.en
dc.publisherAcademic Press Ltd- Elsevier Science Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.rightsrestrictedAccess
dc.sourceBiologicals
dc.subjectAntibody responseen
dc.subjectInfluenza virus strainen
dc.subjectSex differencesen
dc.subjectSplit virus influenza vaccineen
dc.subjectWhole virus influenza vaccineen
dc.titleSex bias in mouse humoral immune response to influenza vaccine depends on the vaccine typeen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage24
dc.citation.other52: 18-24
dc.citation.rankM23
dc.citation.spage18
dc.citation.volume52
dc.identifier.doi10.1016/j.biologicals.2018.01.007
dc.identifier.pmid29426673
dc.identifier.rcubconv_431
dc.identifier.scopus2-s2.0-85044652872
dc.identifier.wos000430880900003
dc.type.versionpublishedVersion


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