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dc.creatorLukić, Ivana
dc.creatorFilipović, Ana
dc.creatorInić-Kanada, Aleksandra
dc.creatorMarinković, Emilija
dc.creatorMiljković, Radmila
dc.creatorStojanović, Marijana
dc.date.accessioned2021-02-18T10:49:57Z
dc.date.available2021-02-18T10:49:57Z
dc.date.issued2018
dc.identifier.issn0264-410X
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/510
dc.description.abstractOligoclonal combinations of several monoclonal antibodies (MAbs) are being considered for the treatment of various infectious pathologies. These combinations are less sensitive to antigen structural changes than individual MAbs; at the same time, their characteristics can be more efficiently controlled than those of polyclonal antibodies. The main goal of this study was to evaluate the binding characteristics of six biclonal equimolar preparations (BEP) of tetanus toxin (TeNT)-specific MAbs and to investigate how the MAb combination influences the BEPs' protective capacity. We show that a combination of TeNT-specific MAbs, which not only bind TeNT but also exert positive cooperative effects, results in a BEP with superior binding characteristics and protective capacity, when compared with the individual component MAbs. Furthermore, we show that a MAb with only partial protective capacity but positive effects on the binding of the other BEP component can be used as a valuable constituent of the BEP. (C) 2018 Elsevier Ltd. All rights reserved.en
dc.publisherElsevier Sci Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.rightsrestrictedAccess
dc.sourceVaccine
dc.subjectAntibodiesen
dc.subjectCooperative effecten
dc.subjectProtectionen
dc.subjectTetanus toxinen
dc.titleCooperative binding of anti-tetanus toxin monoclonal antibodies: Implications for designing an efficient biclonal preparation to prevent tetanus toxin intoxicationen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage3771
dc.citation.issue26
dc.citation.other36(26): 3764-3771
dc.citation.rankM22
dc.citation.spage3764
dc.citation.volume36
dc.identifier.doi10.1016/j.vaccine.2018.05.058
dc.identifier.pmid29773320
dc.identifier.rcubconv_435
dc.identifier.scopus2-s2.0-85047096044
dc.identifier.wos000436216700008
dc.type.versionpublishedVersion


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