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dc.creatorNacka-Aleksić, Mirjana
dc.creatorStojić-Vukanić, Zorica
dc.creatorPilipović, Ivan
dc.creatorVujnović, Ivana
dc.creatorBufan, Biljana
dc.creatorDimitrijević, Mirjana
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:48:35Z
dc.date.available2021-02-18T10:48:35Z
dc.date.issued2017
dc.identifier.issn0047-6374
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/490
dc.description.abstractTo understand strain-specificities of immune system in aged rats and their immunopathological implications, CD4+T lymphocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis (EAE) was studied in two strains. Upon immunization for EAE, 22-24-month-old Albino Oxford (AO) rats developed milder neurological deficit of prolonged duration compared with their Dark Agouti (DA) counterparts. Consistently, they exhibited: (i) diminished neuroantigen-specific CD4+T lymphocyte generation in draining lymph nodes (reflecting lower density of high-affinity IL-2 receptor complex on their surface and higher CD4+FoxP3+CD25+regulatory cell frequency); (ii) less favorable spinal cord expression of CXCL12 and CCL2, and consequently diminished infiltration of neuroantigen-specific CD4+T lymphocytes, including highly pathogenic IL-17+IFN-gamma+ones, and inflammatory monocytes into the spinal cord and (iii) subsequently impaired CD4+T lymphocyte reactivation/survival and differentiation into highly pathogenic IL-17+cells (reflecting downregulated expression of IL-1 beta, IL-6 and IL-23/p19). On the other hand, when the neurological deficit reached maximum/plateau, in AO rat spinal cord was found lower CD4+FoxP3+CD25+ cell frequency followed by higher frequency of IL-10-producing CD8+T cells, which most likely also belong to regulatory T lymphocytes. Thus, the altered relation between regulatory T cell and effector CD4+T cell subsets was linked with persistence of mild neuroinflammation in AO rat EAE model. (C) 2017 Elsevier B.V. All rights reserved.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceMechanisms of Ageing and Development
dc.subjectEAEen
dc.subjectAged ratsen
dc.subjectRat strain differencesen
dc.subjectIL-17+IFN-gamma plus T lymphocytesen
dc.subjectIL-10-producing T cellsen
dc.titleStrain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage163
dc.citation.other164: 146-163
dc.citation.rankM21
dc.citation.spage146
dc.citation.volume164
dc.identifier.doi10.1016/j.mad.2017.03.001
dc.identifier.pmid28284714
dc.identifier.rcubconv_415
dc.identifier.scopus2-s2.0-85015274375
dc.identifier.wos000404502200018
dc.type.versionpublishedVersion


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