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dc.creatorDimitrijević, Mirjana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorStojić-Vukanić, Zorica
dc.creatorVujnović, Ivana
dc.creatorPilipović, Ivan
dc.creatorNacka-Aleksić, Mirjana
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:48:31Z
dc.date.available2021-02-18T10:48:31Z
dc.date.issued2017
dc.identifier.issn0364-3190
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/489
dc.description.abstractThe study examined (a) whether there is sex difference in spinal cord and plasma oxidative stress profiles in Dark Agouti rats immunised for experimental autoimmune encephalomyelitis (EAE), the principal experimental model of multiple sclerosis, and (b) whether there is correlation between the oxidative stress in spinal cord and neurological deficit. Regardless of rat sex, with the disease development xanthine oxidase (XO) activity and inducible nitric oxide synthase (iNOS) mRNA expression increased in spinal cord, whereas glutathione levels decreased. This was accompanied by the rise in spinal cord malondialdehyde level. On the other hand, with EAE development superoxide dismutase (SOD) activity decreased, while O-2 (-) concentration increased only in spinal cord of male rats. Consequently, SOD activity was lower, whereas O-2 (-) concentration was higher in spinal cord of male rats with clinically manifested EAE. XO activity and iNOS mRNA expression were also elevated in their spinal cord. Consistently, in the effector phase of EAE the concentration of advanced oxidation protein product (AOPP) was higher in spinal cord of male rats, which exhibit more severe neurological deficit than their female counterparts. In as much as data obtained in the experimental models could be translated to humans, the findings may be relevant for designing sex-specific antioxidant therapeutic strategies. Furthermore, the study indicated that the increased pro-oxidant-antioxidant balance in plasma may be an early indicator of EAE development. Moreover, it showed that plasma AOPP level may indicate not only actual activity of the disease, but also serve to predict severity of its course.en
dc.publisherSpringer/Plenum Publishers, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceNeurochemical Research
dc.subjectExperimental autoimmune encephalomyelitisen
dc.subjectSex differencesen
dc.subjectMultiple sclerosisen
dc.subjectOxidative stressen
dc.subjectSpinal corden
dc.subjectRaten
dc.titleSex Difference in Oxidative Stress Parameters in Spinal Cord of Rats with Experimental Autoimmune Encephalomyelitis: Relation to Neurological Deficiten
dc.typearticle
dc.rights.licenseARR
dc.citation.epage492
dc.citation.issue2
dc.citation.other42(2): 481-492
dc.citation.rankM22
dc.citation.spage481
dc.citation.volume42
dc.identifier.doi10.1007/s11064-016-2094-7
dc.identifier.pmid27812760
dc.identifier.rcubconv_407
dc.identifier.scopus2-s2.0-84994311207
dc.identifier.wos000395621100015
dc.type.versionpublishedVersion


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