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dc.creatorKovačević-Jovanović, Vesna
dc.creatorMiletić, Tatjana
dc.creatorStanojević, Stanislava
dc.creatorMitić, Katarina
dc.creatorDimitrijević, Mirjana
dc.date.accessioned2021-02-18T10:45:49Z
dc.date.available2021-02-18T10:45:49Z
dc.date.issued2015
dc.identifier.issn1217-8950
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/449
dc.description.abstractWe have investigated the humoral immune response to antigens of predominant gut aerobic bacterial strains (i.e. Escherichia coli) over the course of adjuvant arthritis and oil-induced arthritis in two inbred rat strains: Dark Agouti (DA) and Albino Oxford (AO). We report the presence of antibodies specific to proteins of Escherichia coli in molecular weight range between 20-30 kDa in sera of diseased DA rats, and the absence of these antibodies in the sera of AO rats. In DA rats, CFA and IFA provoked a stronger antibody response to Escherichia coli, especially of the IgG2b antibody class. Intramuscular administration of Escherichia coli preceding the adjuvant arthritis induction had no effect on the development and course of disease, as well as on the activation of T cells in the draining inguinal lymph nodes. Higher serum levels of natural and induced IgA antibodies, combined with a higher CD3(+)CD26(+) cell percentage were found in AO rats. The observed correlation between the serologic response to commensal flora and rats' genetic background as a defining factor for arthritis susceptibility may contribute to the process of creating a favorable (or less favorable) milieu for arthritis development.en
dc.publisherAkademiai Kiado Zrt, Budapest
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsopenAccess
dc.sourceActa Microbiologica et Immunologica Hungarica
dc.subjectadjuvant arthritisen
dc.subjectcommensal bacteriaen
dc.subjectEscherichia colien
dc.subjecthumoral immune responseen
dc.subjectrat strainsen
dc.titleImmune response to gut escherichia coli and susceptibility to adjuvant arthritis in the ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage19
dc.citation.issue1
dc.citation.other62(1): 1-19
dc.citation.rankM23
dc.citation.spage1
dc.citation.volume62
dc.identifier.doi10.1556/AMicr.62.2015.1.1
dc.identifier.fulltexthttp://intor.torlakinstitut.com/bitstream/id/279/446.pdf
dc.identifier.pmid25823450
dc.identifier.rcubconv_359
dc.identifier.scopus2-s2.0-84926289399
dc.identifier.wos000352094200001
dc.type.versionpublishedVersion


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