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dc.creatorPetrušić, Vladimir
dc.creatorTodorović, Nevena
dc.creatorŽivković, Irena
dc.creatorDimitrijević, Rajna
dc.creatorMuhandes, Lina
dc.creatorRajnpreht, Irena
dc.creatorDimitrijević, Ljiljana
dc.date.accessioned2021-02-18T10:45:37Z
dc.date.available2021-02-18T10:45:37Z
dc.date.issued2015
dc.identifier.issn0891-6934
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/446
dc.description.abstractRecent data concerning antiphospholipid syndrome (APS) induction have shown that beta(2)-glycoprotein I (beta(2)GPI) binds lipopolysaccharide (LPS), which results in conformational changes, exposition of a cryptic epitope and possible pathological anti-beta(2)GPI antibody production. In order to investigate the effects of LPS on the induction of APS-related pathology, we performed hyperimmunization of BALB/c and C57BL/6 mice with LPS, alone or in combination with tetanus toxoid (TTd), a protein structurally similar to beta(2)GPI. We report that, although high affinity pathological anti-beta(2)GPI antibodies were produced in all groups of animals, the reproductive pathology was recorded only in mice that received both LPS and TTd, implying on the important roles of both infections and molecular mimicry in APS pathogenesis. Moreover, APS-related reproductive pathology was more pronounced in BALB/c (lowered fertility and fecundity) than C57BL/6 mice (lowered fecundity), which correlated well with the disruption in natural antibody network observed in BALB/c mouse strain.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.relationMinistry of Education, Science and Technological Development of the Republic of Serbia 41021.
dc.rightsrestrictedAccess
dc.sourceAutoimmunity
dc.subjectbeta(2)-glycoprotein Ien
dc.subjectantiphospholipid syndromeen
dc.subjectfertilityen
dc.subjectmolecular mimicryen
dc.subjectnatural antibodiesen
dc.titleAutoantibody response and pregnancy-related pathology induced by combined LPS and tetanus toxoid hyperimmunization in BALB/c and C57BL/6 miceen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage99
dc.citation.issue2
dc.citation.other48(2): 87-99
dc.citation.rankM22
dc.citation.spage87
dc.citation.volume48
dc.identifier.doi10.3109/08916934.2014.961061
dc.identifier.pmid25430703
dc.identifier.rcubconv_356
dc.identifier.scopus2-s2.0-84924975517
dc.identifier.wos000351610300004
dc.type.versionpublishedVersion


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