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Massage-like stroking boosts the immune system in mice
dc.creator | Major, Benjamin | |
dc.creator | Rattazzi, Lorenza | |
dc.creator | Brod, Samuel | |
dc.creator | Pilipović, Ivan | |
dc.creator | Leposavić, Gordana | |
dc.creator | D'Acquisto, Fulvio | |
dc.date.accessioned | 2021-02-18T10:44:43Z | |
dc.date.available | 2021-02-18T10:44:43Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/433 | |
dc.description.abstract | Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p lt 0.05; p lt 0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function. | en |
dc.publisher | Nature Publishing Group, London | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | Massage-like stroking boosts the immune system in mice | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.other | 5 | |
dc.citation.rank | M21 | |
dc.citation.volume | 5 | |
dc.identifier.doi | 10.1038/srep10913 | |
dc.identifier.fulltext | http://intor.torlakinstitut.com/bitstream/id/265/430.pdf | |
dc.identifier.pmid | 26046935 | |
dc.identifier.scopus | 2-s2.0-84930620475 | |
dc.identifier.wos | 000355864900001 | |
dc.type.version | publishedVersion |