Massage-like stroking boosts the immune system in mice
Аутори
Major, BenjaminRattazzi, Lorenza
Brod, Samuel
Pilipović, Ivan
Leposavić, Gordana
D'Acquisto, Fulvio
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p lt 0.05; p lt 0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immun...osuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function.
Извор:
Scientific Reports, 2015, 5Издавач:
- Nature Publishing Group, London
DOI: 10.1038/srep10913
ISSN: 2045-2322
PubMed: 26046935
WoS: 000355864900001
Scopus: 2-s2.0-84930620475
Институција/група
TorlakTY - JOUR AU - Major, Benjamin AU - Rattazzi, Lorenza AU - Brod, Samuel AU - Pilipović, Ivan AU - Leposavić, Gordana AU - D'Acquisto, Fulvio PY - 2015 UR - http://intor.torlakinstitut.com/handle/123456789/433 AB - Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p lt 0.05; p lt 0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function. PB - Nature Publishing Group, London T2 - Scientific Reports T1 - Massage-like stroking boosts the immune system in mice VL - 5 DO - 10.1038/srep10913 ER -
@article{ author = "Major, Benjamin and Rattazzi, Lorenza and Brod, Samuel and Pilipović, Ivan and Leposavić, Gordana and D'Acquisto, Fulvio", year = "2015", abstract = "Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p lt 0.05; p lt 0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function.", publisher = "Nature Publishing Group, London", journal = "Scientific Reports", title = "Massage-like stroking boosts the immune system in mice", volume = "5", doi = "10.1038/srep10913" }
Major, B., Rattazzi, L., Brod, S., Pilipović, I., Leposavić, G.,& D'Acquisto, F.. (2015). Massage-like stroking boosts the immune system in mice. in Scientific Reports Nature Publishing Group, London., 5. https://doi.org/10.1038/srep10913
Major B, Rattazzi L, Brod S, Pilipović I, Leposavić G, D'Acquisto F. Massage-like stroking boosts the immune system in mice. in Scientific Reports. 2015;5. doi:10.1038/srep10913 .
Major, Benjamin, Rattazzi, Lorenza, Brod, Samuel, Pilipović, Ivan, Leposavić, Gordana, D'Acquisto, Fulvio, "Massage-like stroking boosts the immune system in mice" in Scientific Reports, 5 (2015), https://doi.org/10.1038/srep10913 . .