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Sexual dimorphism in the aged rat CD4+T lymphocyte-mediated immune response elicited by inoculation with spinal cord homogenate
dc.creator | Nacka-Aleksić, Mirjana | |
dc.creator | Pilipović, Ivan | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Kosec, Duško | |
dc.creator | Bufan, Biljana | |
dc.creator | Vujnović, Ivana | |
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Dimitrijević, Mirjana | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2021-02-18T10:44:35Z | |
dc.date.available | 2021-02-18T10:44:35Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0047-6374 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/431 | |
dc.description.abstract | Considering the crucial pathogenic role of CD4+ T cells in experimental autoimmune encephalomyelitis (EAE) and the opposite direction of the sexual dimorphism in the severity of the disease in 22-24-and 3-month-old dark agouti rats, sex differences in CD4+ T-cell-mediated immune response in aged rats immunized for EAE were examined and compared with those in young animals. In the inductive phase of EAE, fewer activated CD4+ lymphocytes were-retrieved from draining lymph nodes of male (developing less severe disease) compared with female rats, due, at least partly, to their lesser expansion. The former reflected a greater suppressive capacity of CD4+CD25+Foxp3+ cells. Consequently, CD4+ lymphocyte infiltration into the spinal cord of aged male rats was diminished. At the peak of EAE, the frequency of reactivated cells was lower, whereas that of the regulatory CD4+ cells was higher in male rat spinal cord. Consistently, microglial activation and the expression of proinflammatory/damaging cytokines in male rat spinal cord mononuclear cells were diminished. Additionally, the frequency of the highly pathogenic IL-17+IFN-gamma+ T lymphocytes infiltrating their spinal cord was lower. Together, these results point to (i) an age-specificity in CD4+ cell-mediated immune response and (ii) mechanisms underlying the sex differences in this response in aged rats. (C) 2015 Elsevier Ireland Ltd. All rights reserved. | en |
dc.publisher | Elsevier Ireland Ltd, Clare | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Mechanisms of Ageing and Development | |
dc.subject | Sexual dimorphism | en |
dc.subject | Aging | en |
dc.subject | EAE | en |
dc.subject | CD4+CD25+Foxp3+lymphocytes | en |
dc.subject | IL-17+IFN-gamma plus lymphocytes | en |
dc.title | Sexual dimorphism in the aged rat CD4+T lymphocyte-mediated immune response elicited by inoculation with spinal cord homogenate | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 31 | |
dc.citation.other | 152: 15-31 | |
dc.citation.rank | M22 | |
dc.citation.spage | 15 | |
dc.citation.volume | 152 | |
dc.identifier.doi | 10.1016/j.mad.2015.09.004 | |
dc.identifier.pmid | 26408399 | |
dc.identifier.scopus | 2-s2.0-84944089002 | |
dc.identifier.wos | 000366772300003 | |
dc.type.version | publishedVersion |