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dc.creatorNacka-Aleksić, Mirjana
dc.creatorPilipović, Ivan
dc.creatorStojić-Vukanić, Zorica
dc.creatorKosec, Duško
dc.creatorBufan, Biljana
dc.creatorVujnović, Ivana
dc.creatorArsenović-Ranin, Nevena
dc.creatorDimitrijević, Mirjana
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-18T10:44:35Z
dc.date.available2021-02-18T10:44:35Z
dc.date.issued2015
dc.identifier.issn0047-6374
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/431
dc.description.abstractConsidering the crucial pathogenic role of CD4+ T cells in experimental autoimmune encephalomyelitis (EAE) and the opposite direction of the sexual dimorphism in the severity of the disease in 22-24-and 3-month-old dark agouti rats, sex differences in CD4+ T-cell-mediated immune response in aged rats immunized for EAE were examined and compared with those in young animals. In the inductive phase of EAE, fewer activated CD4+ lymphocytes were-retrieved from draining lymph nodes of male (developing less severe disease) compared with female rats, due, at least partly, to their lesser expansion. The former reflected a greater suppressive capacity of CD4+CD25+Foxp3+ cells. Consequently, CD4+ lymphocyte infiltration into the spinal cord of aged male rats was diminished. At the peak of EAE, the frequency of reactivated cells was lower, whereas that of the regulatory CD4+ cells was higher in male rat spinal cord. Consistently, microglial activation and the expression of proinflammatory/damaging cytokines in male rat spinal cord mononuclear cells were diminished. Additionally, the frequency of the highly pathogenic IL-17+IFN-gamma+ T lymphocytes infiltrating their spinal cord was lower. Together, these results point to (i) an age-specificity in CD4+ cell-mediated immune response and (ii) mechanisms underlying the sex differences in this response in aged rats. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceMechanisms of Ageing and Development
dc.subjectSexual dimorphismen
dc.subjectAgingen
dc.subjectEAEen
dc.subjectCD4+CD25+Foxp3+lymphocytesen
dc.subjectIL-17+IFN-gamma plus lymphocytesen
dc.titleSexual dimorphism in the aged rat CD4+T lymphocyte-mediated immune response elicited by inoculation with spinal cord homogenateen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage31
dc.citation.other152: 15-31
dc.citation.rankM22
dc.citation.spage15
dc.citation.volume152
dc.identifier.doi10.1016/j.mad.2015.09.004
dc.identifier.pmid26408399
dc.identifier.rcubconv_374
dc.identifier.scopus2-s2.0-84944089002
dc.identifier.wos000366772300003
dc.type.versionpublishedVersion


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