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Ovarian hormone level alterations during rat post-reproductive life-span influence CD8+T-cell homeostasis
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Kosec, Duško | |
dc.creator | Nacka-Aleksić, Mirjana | |
dc.creator | Pilipović, Ivan | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Đikić, Jasmina | |
dc.creator | Bufan, Biljana | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2021-02-18T10:44:27Z | |
dc.date.available | 2021-02-18T10:44:27Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1535-3702 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/429 | |
dc.description.abstract | The study examined the putative role of ovarian hormones in shaping of rat peripheral T-cell compartment during post-reproductive period. In 20-month-old rats ovariectomized (Ox) at the very end of reproductive period, thymic output, cellularity and composition of major TCR alpha beta+peripheral blood lymphocyte and splenocyte subsets were analyzed. Ovariectomy led to the enlargement of CD8 + peripheral blood lymphocyte and splenocyte subpopulations. This reflected: (i) a more efficient thymic generation of CD8 + cells as indicated by increased number of CD4+CD8+double positive and the most mature CD4CD8+TCR alpha beta(high) thymocytes and CD8 + recent thymic emigrants (RTEs) in peripheral blood, but not in the spleen of Ox rats, and (ii) the expansion of CD8 + memory/activated peripheral blood lymphocytes and splenocytes. The latter was consistent with a greater frequency of proliferating cells among freshly isolated memory/activated CD8 + peripheral blood lymphocytes and splenocytes and increased proliferative response of CD8 + splenocytes to stimulation with plate-bound anti-CD3 antibody. The former could be related to the rise in splenic IL-7 and IL-15 mRNA expression. Although ovariectomy affected the overall number of CD4 + T cells in none of the examined compartments, it increased CD4+FoxP3 + peripheral blood lymphocyte and splenocyte counts by enhancing their generation in periphery. Collectively, the results suggest that ovariectomy-induced long-lasting disturbances in ovarian hormone levels (mirrored in diminished progesterone serum level in 20-month-old rats) affects both thymic CD8 + cell generation and peripheral homeostasis and leads to the expansion of CD4+FoxP3 + cells in the periphery, thereby enhancing autoreactive cell control on account of immune system efficacy to combat infections and tumors. | en |
dc.publisher | Sage Publications Ltd, London | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | openAccess | |
dc.source | Experimental Biology and Medicine | |
dc.subject | Ovarian gland hormones | en |
dc.subject | mature naive T cells | en |
dc.subject | memory/activated T cells | en |
dc.subject | regulatory T cells T-cell proliferation/apoptosis | en |
dc.title | Ovarian hormone level alterations during rat post-reproductive life-span influence CD8+T-cell homeostasis | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1332 | |
dc.citation.issue | 10 | |
dc.citation.other | 240(10): 1319-1332 | |
dc.citation.rank | M22 | |
dc.citation.spage | 1319 | |
dc.citation.volume | 240 | |
dc.identifier.doi | 10.1177/1535370215570817 | |
dc.identifier.fulltext | http://intor.torlakinstitut.com/bitstream/id/261/426.pdf | |
dc.identifier.pmid | 25716018 | |
dc.identifier.scopus | 2-s2.0-84942844167 | |
dc.identifier.wos | 000362190300007 | |
dc.type.version | publishedVersion |