This study investigated a putative contribution of mast cells and C-sensory fibers to differences in the development of inflammatory edema following the injection of concanavalin A (Con A) into the hind paws of Dark Agouti (DA) and Albino Oxford (AO) rats. The treatment of adult rats with mast cell-depletor compound 48/80 and neonatal depletion of C-sensory fibers independently revealed that leukocyte composition of the inflamed paws and lymph nodes during local inflammatory response to Con A was generally regulated in a similar way in DA and AO rat strains. However, in DA and AO rats, the decrease and the increase of Con A-induced plasma extravasation were associated with mast cell depletion and activation, respectively, whereas neonatal capsaicin treatment activated dermal mast cells and potentiated inflammatory plasma extravasation only in adult rats of DA strain. Hence, strain differences in Emphasis Type="Strikethrough" the development of the inflammatory response to Con A are pro...bably controlled by the differences in the interplay between mast cells and C-sensory fibers in DA and AO rats.
Keywords:
concanavalin A (Con A) / paw edema / mast cells / C-sensory fibers / Dark Agouti (DA) and Albino Oxford (AO) rat strains
TY - JOUR
AU - Stanojević, Stanislava
AU - Kuštrimović, Nataša
AU - Mitić, Katarina
AU - Vujić, Vesna
AU - Dimitrijević, Mirjana
PY - 2015
UR - http://intor.torlakinstitut.com/handle/123456789/424
AB - This study investigated a putative contribution of mast cells and C-sensory fibers to differences in the development of inflammatory edema following the injection of concanavalin A (Con A) into the hind paws of Dark Agouti (DA) and Albino Oxford (AO) rats. The treatment of adult rats with mast cell-depletor compound 48/80 and neonatal depletion of C-sensory fibers independently revealed that leukocyte composition of the inflamed paws and lymph nodes during local inflammatory response to Con A was generally regulated in a similar way in DA and AO rat strains. However, in DA and AO rats, the decrease and the increase of Con A-induced plasma extravasation were associated with mast cell depletion and activation, respectively, whereas neonatal capsaicin treatment activated dermal mast cells and potentiated inflammatory plasma extravasation only in adult rats of DA strain. Hence, strain differences in Emphasis Type="Strikethrough" the development of the inflammatory response to Con A are probably controlled by the differences in the interplay between mast cells and C-sensory fibers in DA and AO rats.
PB - Springer/Plenum Publishers, New York
T2 - Inflammation
T1 - Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains
EP - 1449
IS - 4
SP - 1434
VL - 38
DO - 10.1007/s10753-015-0118-0
ER -
@article{
author = "Stanojević, Stanislava and Kuštrimović, Nataša and Mitić, Katarina and Vujić, Vesna and Dimitrijević, Mirjana",
year = "2015",
url = "http://intor.torlakinstitut.com/handle/123456789/424",
abstract = "This study investigated a putative contribution of mast cells and C-sensory fibers to differences in the development of inflammatory edema following the injection of concanavalin A (Con A) into the hind paws of Dark Agouti (DA) and Albino Oxford (AO) rats. The treatment of adult rats with mast cell-depletor compound 48/80 and neonatal depletion of C-sensory fibers independently revealed that leukocyte composition of the inflamed paws and lymph nodes during local inflammatory response to Con A was generally regulated in a similar way in DA and AO rat strains. However, in DA and AO rats, the decrease and the increase of Con A-induced plasma extravasation were associated with mast cell depletion and activation, respectively, whereas neonatal capsaicin treatment activated dermal mast cells and potentiated inflammatory plasma extravasation only in adult rats of DA strain. Hence, strain differences in Emphasis Type="Strikethrough" the development of the inflammatory response to Con A are probably controlled by the differences in the interplay between mast cells and C-sensory fibers in DA and AO rats.",
publisher = "Springer/Plenum Publishers, New York",
journal = "Inflammation",
title = "Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains",
pages = "1449-1434",
number = "4",
volume = "38",
doi = "10.1007/s10753-015-0118-0"
}
Stanojević, S., Kuštrimović, N., Mitić, K., Vujić, V.,& Dimitrijević, M. (2015). Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains.
Inflammation
Springer/Plenum Publishers, New York., 38(4), 1434-1449.
https://doi.org/10.1007/s10753-015-0118-0
Stanojević S, Kuštrimović N, Mitić K, Vujić V, Dimitrijević M. Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains. Inflammation. 2015;38(4):1434-1449
Stanojević Stanislava, Kuštrimović Nataša, Mitić Katarina, Vujić Vesna, Dimitrijević Mirjana, "Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains" Inflammation, 38, no. 4 (2015):1434-1449,
https://doi.org/10.1007/s10753-015-0118-0 .
