InTOR - Repository of the Institute “Torlak”
Institute of Virology, Vaccines and Sera “Torlak”
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   InTOR
  • Torlak
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   InTOR
  • Torlak
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Infection-induced autoantibodies and pregnancy related pathology: an animal model

Authorized Users Only
2014
Authors
Petrušić, Vladimir
Živković, Irena
Muhandes, Lina
Dimitrijević, Rajna
Stojanović, Marijana
Dimitrijević, Ljiljana
Article (Published version)
Metadata
Show full item record
Abstract
In addition to being the main cause of mortality worldwide, bacterial and viral infections can be the cause of autoimmune and pregnancy disorders as well. The production of autoantibodies during infection can be explained by various mechanisms, including molecular mimicry, bystander cell activation and epitope spreading. Conversely, bacterial and viral infections during pregnancy are especially dangerous for the fetus. It is documented that infection-induced inflammatory processes mediated by Toll-like receptors (TLR) represent the main cause of preterm labour. We used two crucial bacterial components and TLR ligands, namely peptidoglycan and lipopolysaccharide, to stimulate BALB/c mice before immunisation with tetanus toxoid. Tetanus toxoid is an inactive form of the toxin produced by bacterium Clostridium tetani and shares structural similarity with plasma protein beta(2)-glycoprotein I. Treatment with peptidoglycan and lipopolysaccharide in combination with tetanus toxoid induced th...e production of pathological autoantibodies, different fluctuations in natural autoantibodies and different types of reproductive pathology in treated animals, with peptidoglycan treatment being more deleterious. We propose that the production of pathological autoantibodies, TLR activation and changes in natural autoantibodies play crucial roles in infection-induced reproductive pathology in our animal model.

Keywords:
fecundity, fertility, lipopolysaccharide, peptidoglycan, reproductive pathology.
Source:
Reproduction Fertility and Development, 2014, 26, 4, 578-586
Publisher:
  • Csiro Publishing, Clayton
Funding / projects:
  • Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-172049)
  • 41021

DOI: 10.1071/RD13057

ISSN: 1031-3613

PubMed: 23657219

WoS: 000333923600011

Scopus: 2-s2.0-84898032759
[ Google Scholar ]
6
5
URI
http://intor.torlakinstitut.com/handle/123456789/399
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Petrušić, Vladimir
AU  - Živković, Irena
AU  - Muhandes, Lina
AU  - Dimitrijević, Rajna
AU  - Stojanović, Marijana
AU  - Dimitrijević, Ljiljana
PY  - 2014
UR  - http://intor.torlakinstitut.com/handle/123456789/399
AB  - In addition to being the main cause of mortality worldwide, bacterial and viral infections can be the cause of autoimmune and pregnancy disorders as well. The production of autoantibodies during infection can be explained by various mechanisms, including molecular mimicry, bystander cell activation and epitope spreading. Conversely, bacterial and viral infections during pregnancy are especially dangerous for the fetus. It is documented that infection-induced inflammatory processes mediated by Toll-like receptors (TLR) represent the main cause of preterm labour. We used two crucial bacterial components and TLR ligands, namely peptidoglycan and lipopolysaccharide, to stimulate BALB/c mice before immunisation with tetanus toxoid. Tetanus toxoid is an inactive form of the toxin produced by bacterium Clostridium tetani and shares structural similarity with plasma protein beta(2)-glycoprotein I. Treatment with peptidoglycan and lipopolysaccharide in combination with tetanus toxoid induced the production of pathological autoantibodies, different fluctuations in natural autoantibodies and different types of reproductive pathology in treated animals, with peptidoglycan treatment being more deleterious. We propose that the production of pathological autoantibodies, TLR activation and changes in natural autoantibodies play crucial roles in infection-induced reproductive pathology in our animal model.
PB  - Csiro Publishing, Clayton
T2  - Reproduction Fertility and Development
T1  - Infection-induced autoantibodies and pregnancy related pathology: an animal model
EP  - 586
IS  - 4
SP  - 578
VL  - 26
DO  - 10.1071/RD13057
UR  - conv_337
ER  - 
@article{
author = "Petrušić, Vladimir and Živković, Irena and Muhandes, Lina and Dimitrijević, Rajna and Stojanović, Marijana and Dimitrijević, Ljiljana",
year = "2014",
abstract = "In addition to being the main cause of mortality worldwide, bacterial and viral infections can be the cause of autoimmune and pregnancy disorders as well. The production of autoantibodies during infection can be explained by various mechanisms, including molecular mimicry, bystander cell activation and epitope spreading. Conversely, bacterial and viral infections during pregnancy are especially dangerous for the fetus. It is documented that infection-induced inflammatory processes mediated by Toll-like receptors (TLR) represent the main cause of preterm labour. We used two crucial bacterial components and TLR ligands, namely peptidoglycan and lipopolysaccharide, to stimulate BALB/c mice before immunisation with tetanus toxoid. Tetanus toxoid is an inactive form of the toxin produced by bacterium Clostridium tetani and shares structural similarity with plasma protein beta(2)-glycoprotein I. Treatment with peptidoglycan and lipopolysaccharide in combination with tetanus toxoid induced the production of pathological autoantibodies, different fluctuations in natural autoantibodies and different types of reproductive pathology in treated animals, with peptidoglycan treatment being more deleterious. We propose that the production of pathological autoantibodies, TLR activation and changes in natural autoantibodies play crucial roles in infection-induced reproductive pathology in our animal model.",
publisher = "Csiro Publishing, Clayton",
journal = "Reproduction Fertility and Development",
title = "Infection-induced autoantibodies and pregnancy related pathology: an animal model",
pages = "586-578",
number = "4",
volume = "26",
doi = "10.1071/RD13057",
url = "conv_337"
}
Petrušić, V., Živković, I., Muhandes, L., Dimitrijević, R., Stojanović, M.,& Dimitrijević, L.. (2014). Infection-induced autoantibodies and pregnancy related pathology: an animal model. in Reproduction Fertility and Development
Csiro Publishing, Clayton., 26(4), 578-586.
https://doi.org/10.1071/RD13057
conv_337
Petrušić V, Živković I, Muhandes L, Dimitrijević R, Stojanović M, Dimitrijević L. Infection-induced autoantibodies and pregnancy related pathology: an animal model. in Reproduction Fertility and Development. 2014;26(4):578-586.
doi:10.1071/RD13057
conv_337 .
Petrušić, Vladimir, Živković, Irena, Muhandes, Lina, Dimitrijević, Rajna, Stojanović, Marijana, Dimitrijević, Ljiljana, "Infection-induced autoantibodies and pregnancy related pathology: an animal model" in Reproduction Fertility and Development, 26, no. 4 (2014):578-586,
https://doi.org/10.1071/RD13057 .,
conv_337 .

DSpace software copyright © 2002-2015  DuraSpace
About InTOR | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About InTOR | Send Feedback

OpenAIRERCUB