Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery

Perišić, Milica; Stojić-Vukanić, Zorica; Pilipović, Ivan; Kosec, Duško; Nacka-Aleksić, Mirjana; Đikić, Jasmina; Arsenović-Ranin, Nevena; Leposavić, Gordana

doi:10.1016/j.imbio.2012.05.009

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2013

Authors

Perišić, Milica
Stojić-Vukanić, Zorica

Pilipović, Ivan

Kosec, Duško
Nacka-Aleksić, Mirjana

Đikić, Jasmina
Arsenović-Ranin, Nevena

Leposavić, Gordana

Article (Published version)

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Abstract

The study explored the putative role of ovarian hormones in the peripubertal remodelling of peripheral T-cell compartment. Ovariectomy at age of 1 month enhanced the peripubertal rise in CD4+ and CD8+ cell numbers in peripheral blood (PB) and spleen from 2-month-old rats. This reflected maintenance of thymopoietic efficiency at the prepubertal level (judging by numbers of the most mature CD4+ and CD8+ thymocytes and recent thymic emigrants) and alterations in T-cell survival/proliferation in the periphery. Compared with age-matched controls, the frequency of apoptotic cells among CD8+ peripheral blood lymphocytes (PBLs) and CD4+ and CD8+ splenocytes was diminished in ovariectomized (Ox) rats, at least partly, due to lower CD95 surface density. The diminished frequency of the apoptotic T splenocytes could also be associated with the rise in the amount of splenic IL-7 mRNA. Additionally, the latter finding was consistent with the augmented proliferation of CD4+ and CD8+ splenocytes. Howe...

Keywords:

Peripubertal development / Ovarian hormones / T-cell proliferation / T-cell apoptosis / Peripheral T-cell maturation / Immunoregulatory T-cells

Source:
Immunobiology, 2013, 218, 3, 353-367

Publisher:

Elsevier Gmbh, Urban & Fischer Verlag, Jena

Projects:

DOI: 10.1016/j.imbio.2012.05.009

ISSN: 0171-2985

PubMed: 22704521

WoS: 000316235700008

Scopus: 2-s2.0-84873258455

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TY - JOUR
AU - Perišić, Milica
AU - Stojić-Vukanić, Zorica
AU - Pilipović, Ivan
AU - Kosec, Duško
AU - Nacka-Aleksić, Mirjana
AU - Đikić, Jasmina
AU - Arsenović-Ranin, Nevena
AU - Leposavić, Gordana
PY - 2013
UR - http://intor.torlakinstitut.com/handle/123456789/396
AB - The study explored the putative role of ovarian hormones in the peripubertal remodelling of peripheral T-cell compartment. Ovariectomy at age of 1 month enhanced the peripubertal rise in CD4+ and CD8+ cell numbers in peripheral blood (PB) and spleen from 2-month-old rats. This reflected maintenance of thymopoietic efficiency at the prepubertal level (judging by numbers of the most mature CD4+ and CD8+ thymocytes and recent thymic emigrants) and alterations in T-cell survival/proliferation in the periphery. Compared with age-matched controls, the frequency of apoptotic cells among CD8+ peripheral blood lymphocytes (PBLs) and CD4+ and CD8+ splenocytes was diminished in ovariectomized (Ox) rats, at least partly, due to lower CD95 surface density. The diminished frequency of the apoptotic T splenocytes could also be associated with the rise in the amount of splenic IL-7 mRNA. Additionally, the latter finding was consistent with the augmented proliferation of CD4+ and CD8+ splenocytes. However, the enhanced proliferation of these cells could also be linked to the rise in IL-2 receptor surface density. This increase was related to the enhanced splenic TNF-alpha mRNA expression. Additionally, ovariectomy led to the phenotypic alterations in the major PBL and splenic T-cell subsets by diminishing/preventing the peripubertal changes in the frequency of cells at distinct stages of post-thymic differentiation/maturation (recent thymic emigrants, mature naive and memory cells), and by decreasing the frequency of NKT cells within peripheral CD8+ subsets. In addition to numerical and phenotypic changes in T-cell compartment (due to the lack of ovarian hormone action at both the thymic and peripheral level), Ox rats exhibited a much larger delayed-type hypersensitivity (DTH) response compared with age-matched controls. This suggested the augmented T-cell-mediated immune response in Ox rats compared with aged-matched controls. (C) 2012 Elsevier GmbH. All rights reserved.
PB - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2 - Immunobiology
T1 - Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery
EP - 367
IS - 3
SP - 353
VL - 218
DO - 10.1016/j.imbio.2012.05.009
ER -

@article{
author = "Perišić, Milica and Stojić-Vukanić, Zorica and Pilipović, Ivan and Kosec, Duško and Nacka-Aleksić, Mirjana and Đikić, Jasmina and Arsenović-Ranin, Nevena and Leposavić, Gordana",
year = "2013",
url = "http://intor.torlakinstitut.com/handle/123456789/396",
abstract = "The study explored the putative role of ovarian hormones in the peripubertal remodelling of peripheral T-cell compartment. Ovariectomy at age of 1 month enhanced the peripubertal rise in CD4+ and CD8+ cell numbers in peripheral blood (PB) and spleen from 2-month-old rats. This reflected maintenance of thymopoietic efficiency at the prepubertal level (judging by numbers of the most mature CD4+ and CD8+ thymocytes and recent thymic emigrants) and alterations in T-cell survival/proliferation in the periphery. Compared with age-matched controls, the frequency of apoptotic cells among CD8+ peripheral blood lymphocytes (PBLs) and CD4+ and CD8+ splenocytes was diminished in ovariectomized (Ox) rats, at least partly, due to lower CD95 surface density. The diminished frequency of the apoptotic T splenocytes could also be associated with the rise in the amount of splenic IL-7 mRNA. Additionally, the latter finding was consistent with the augmented proliferation of CD4+ and CD8+ splenocytes. However, the enhanced proliferation of these cells could also be linked to the rise in IL-2 receptor surface density. This increase was related to the enhanced splenic TNF-alpha mRNA expression. Additionally, ovariectomy led to the phenotypic alterations in the major PBL and splenic T-cell subsets by diminishing/preventing the peripubertal changes in the frequency of cells at distinct stages of post-thymic differentiation/maturation (recent thymic emigrants, mature naive and memory cells), and by decreasing the frequency of NKT cells within peripheral CD8+ subsets. In addition to numerical and phenotypic changes in T-cell compartment (due to the lack of ovarian hormone action at both the thymic and peripheral level), Ox rats exhibited a much larger delayed-type hypersensitivity (DTH) response compared with age-matched controls. This suggested the augmented T-cell-mediated immune response in Ox rats compared with aged-matched controls. (C) 2012 Elsevier GmbH. All rights reserved.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Immunobiology",
title = "Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery",
pages = "367-353",
number = "3",
volume = "218",
doi = "10.1016/j.imbio.2012.05.009"
}

Perišić, M., Stojić-Vukanić, Z., Pilipović, I., Kosec, D., Nacka-Aleksić, M., Đikić, J., Arsenović-Ranin, N.,& Leposavić, G. (2013). Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery.
Immunobiology
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 218(3), 353-367.
https://doi.org/10.1016/j.imbio.2012.05.009

Perišić M, Stojić-Vukanić Z, Pilipović I, Kosec D, Nacka-Aleksić M, Đikić J, Arsenović-Ranin N, Leposavić G. Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery. Immunobiology. 2013;218(3):353-367

Perišić Milica, Stojić-Vukanić Zorica, Pilipović Ivan, Kosec Duško, Nacka-Aleksić Mirjana, Đikić Jasmina, Arsenović-Ranin Nevena, Leposavić Gordana, "Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery" Immunobiology, 218, no. 3 (2013):353-367,
https://doi.org/10.1016/j.imbio.2012.05.009 .