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dc.creatorCukić, Milena
dc.creatorOommen, J.
dc.creatorMutavdžić, D.
dc.creatorJorgovanović, N.
dc.creatorLjubisavljević, M.
dc.date.accessioned2021-02-18T10:41:49Z
dc.date.available2021-02-18T10:41:49Z
dc.date.issued2013
dc.identifier.issn0014-4819
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/392
dc.description.abstractThe aim of this study was to examine whether single-pulse transcranial magnetic stimulation (spTMS) affects the pattern of corticospinal activity once voluntary drive has been restored after spTMS-induced EMG silence. We used fractal dimension (FD) to explore the 'complexity' of the electromyography (EMG) signal, and median frequency of the spectra (MDF) to examine changes in EMG spectral characteristics. FD and MDF of the raw EMG epochs immediately before were compared with those obtained from epochs after the EMG silence. Changes in FD and MDF after spTMS were examined with three levels of muscle contraction corresponding to weak (20-40 %), moderate (40-60 %) and strong (60-80 % of maximal voluntary contraction) and three intensities of stimulation set at 10, 20 and 30 % above the resting motor threshold. FD was calculated using the Higuchi fractal dimension algorithm. Finally, to discern the origin of FD changes between the CNS and muscle, we compared the effects of spTMS with the effects of peripheral nerve stimulation (PNS) on FD and MDF. The results show that spTMS induced significant decrease in both FD and MDF of EMG signal after stimulation. PNS did not have any significant effects on FD nor MDF. Changes in TMS intensity did not have any significant effect on FD or MDF after stimulation nor had the strength of muscle contraction. However, increase in contraction strength decreased FD before stimulation but only between weak and moderate contraction. The results suggest that the effects of spTMS on corticospinal activity, underlying voluntary motor output, outlast the TMS stimulus. It appears that the complexity of the EMG signal is reduced after spTMS, suggesting that TMS alters the dynamics of the ongoing corticospinal activity most likely temporarily synchronizing the neural network activity. Further studies are needed to confirm whether observed changes after TMS occur at the cortical level.en
dc.publisherSpringer, New York
dc.relationFMHS UAE University Grant
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175090/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175012/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43011/RS//
dc.rightsrestrictedAccess
dc.sourceExperimental Brain Research
dc.subjectEMGen
dc.subjectTMSen
dc.subjectPeripheral nerve stimulationen
dc.subjectFractal dimensionen
dc.subjectComplexityen
dc.titleThe effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysisen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage104
dc.citation.issue1
dc.citation.other228(1): 97-104
dc.citation.rankM23
dc.citation.spage97
dc.citation.volume228
dc.identifier.doi10.1007/s00221-013-3541-1
dc.identifier.pmid23652725
dc.identifier.rcubconv_307
dc.identifier.scopus2-s2.0-84879083529
dc.identifier.wos000320313000009
dc.type.versionpublishedVersion


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