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Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant
dc.creator | Živković, Irena | |
dc.creator | Petrušić, Vladimir | |
dc.creator | Stojanović, Marijana | |
dc.creator | Inić-Kanada, Aleksandra | |
dc.creator | Lukić, Ivana | |
dc.creator | Dimitrijević, Ljiljana | |
dc.date.accessioned | 2021-02-18T10:39:38Z | |
dc.date.available | 2021-02-18T10:39:38Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1753-4259 | |
dc.identifier.uri | http://intor.torlakinstitut.com/handle/123456789/363 | |
dc.description.abstract | It has already been shown that tetanus toxoid (TTd) hyper-immunization is a suitable experimental method for creating the animal model of antiphospholipid syndrome (APS) in BALB/c mice. The severity of APS pathology in BALB/c mice mainly correlates to the affinity of anti-beta(2) glycoprotein I (beta(2)GPI) antibodies. In this study we have investigated reproductive pathology induced in C57BL/6 mice by TTd hyper-immunization using a combination of different pretreatments (complete Freund's adjuvant or glycerol) and adjuvants (alhydrogel or glycerol). A decrease in fecundity was recorded in only C57BL/6 mice immunized with alhydrogel adjuvant, irrespective of the kind of applied pretreatment; it was associated with an increase in abundance of low affinity anti-beta(2)GPI IgG antibodies and Th1 prevalence. | en |
dc.publisher | Sage Publications Ltd, London | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS// | |
dc.rights | restrictedAccess | |
dc.source | Innate Immunity | |
dc.subject | Alhydrogel | en |
dc.subject | antiphospholipid syndrome | en |
dc.subject | C57BL/6 mice | en |
dc.subject | fecundity | en |
dc.subject | natural antibodies | en |
dc.title | Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 342 | |
dc.citation.issue | 2 | |
dc.citation.other | 18(2): 333-342 | |
dc.citation.rank | M22 | |
dc.citation.spage | 333 | |
dc.citation.volume | 18 | |
dc.identifier.doi | 10.1177/1753425911407361 | |
dc.identifier.pmid | 21926163 | |
dc.identifier.scopus | 2-s2.0-84858423109 | |
dc.identifier.wos | 000301521100014 | |
dc.type.version | publishedVersion |