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dc.creatorŽivković, Irena
dc.creatorPetrušić, Vladimir
dc.creatorStojanović, Marijana
dc.creatorInić-Kanada, Aleksandra
dc.creatorLukić, Ivana
dc.creatorDimitrijević, Ljiljana
dc.date.accessioned2021-02-18T10:39:38Z
dc.date.available2021-02-18T10:39:38Z
dc.date.issued2012
dc.identifier.issn1753-4259
dc.identifier.urihttp://intor.torlakinstitut.com/handle/123456789/363
dc.description.abstractIt has already been shown that tetanus toxoid (TTd) hyper-immunization is a suitable experimental method for creating the animal model of antiphospholipid syndrome (APS) in BALB/c mice. The severity of APS pathology in BALB/c mice mainly correlates to the affinity of anti-beta(2) glycoprotein I (beta(2)GPI) antibodies. In this study we have investigated reproductive pathology induced in C57BL/6 mice by TTd hyper-immunization using a combination of different pretreatments (complete Freund's adjuvant or glycerol) and adjuvants (alhydrogel or glycerol). A decrease in fecundity was recorded in only C57BL/6 mice immunized with alhydrogel adjuvant, irrespective of the kind of applied pretreatment; it was associated with an increase in abundance of low affinity anti-beta(2)GPI IgG antibodies and Th1 prevalence.en
dc.publisherSage Publications Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.rightsrestrictedAccess
dc.sourceInnate Immunity
dc.subjectAlhydrogelen
dc.subjectantiphospholipid syndromeen
dc.subjectC57BL/6 miceen
dc.subjectfecundityen
dc.subjectnatural antibodiesen
dc.titleInduction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvanten
dc.typearticle
dc.rights.licenseARR
dc.citation.epage342
dc.citation.issue2
dc.citation.other18(2): 333-342
dc.citation.rankM22
dc.citation.spage333
dc.citation.volume18
dc.identifier.doi10.1177/1753425911407361
dc.identifier.pmid21926163
dc.identifier.scopus2-s2.0-84858423109
dc.identifier.wos000301521100014
dc.type.versionpublishedVersion


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