Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant
Samo za registrovane korisnike
2012
Autori
Živković, IrenaPetrušić, Vladimir
Stojanović, Marijana
Inić-Kanada, Aleksandra
Lukić, Ivana
Dimitrijević, Ljiljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
It has already been shown that tetanus toxoid (TTd) hyper-immunization is a suitable experimental method for creating the animal model of antiphospholipid syndrome (APS) in BALB/c mice. The severity of APS pathology in BALB/c mice mainly correlates to the affinity of anti-beta(2) glycoprotein I (beta(2)GPI) antibodies. In this study we have investigated reproductive pathology induced in C57BL/6 mice by TTd hyper-immunization using a combination of different pretreatments (complete Freund's adjuvant or glycerol) and adjuvants (alhydrogel or glycerol). A decrease in fecundity was recorded in only C57BL/6 mice immunized with alhydrogel adjuvant, irrespective of the kind of applied pretreatment; it was associated with an increase in abundance of low affinity anti-beta(2)GPI IgG antibodies and Th1 prevalence.
Ključne reči:
Alhydrogel / antiphospholipid syndrome / C57BL/6 mice / fecundity / natural antibodiesIzvor:
Innate Immunity, 2012, 18, 2, 333-342Izdavač:
- Sage Publications Ltd, London
Finansiranje / projekti:
- Alergeni, antitela, enzimi i mali fiziološki značajni molekuli: dizajn, struktura, funkcija i značaj (RS-MESTD-Basic Research (BR or ON)-172049)
DOI: 10.1177/1753425911407361
ISSN: 1753-4259
PubMed: 21926163
WoS: 000301521100014
Scopus: 2-s2.0-84858423109
Institucija/grupa
TorlakTY - JOUR AU - Živković, Irena AU - Petrušić, Vladimir AU - Stojanović, Marijana AU - Inić-Kanada, Aleksandra AU - Lukić, Ivana AU - Dimitrijević, Ljiljana PY - 2012 UR - http://intor.torlakinstitut.com/handle/123456789/363 AB - It has already been shown that tetanus toxoid (TTd) hyper-immunization is a suitable experimental method for creating the animal model of antiphospholipid syndrome (APS) in BALB/c mice. The severity of APS pathology in BALB/c mice mainly correlates to the affinity of anti-beta(2) glycoprotein I (beta(2)GPI) antibodies. In this study we have investigated reproductive pathology induced in C57BL/6 mice by TTd hyper-immunization using a combination of different pretreatments (complete Freund's adjuvant or glycerol) and adjuvants (alhydrogel or glycerol). A decrease in fecundity was recorded in only C57BL/6 mice immunized with alhydrogel adjuvant, irrespective of the kind of applied pretreatment; it was associated with an increase in abundance of low affinity anti-beta(2)GPI IgG antibodies and Th1 prevalence. PB - Sage Publications Ltd, London T2 - Innate Immunity T1 - Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant EP - 342 IS - 2 SP - 333 VL - 18 DO - 10.1177/1753425911407361 ER -
@article{ author = "Živković, Irena and Petrušić, Vladimir and Stojanović, Marijana and Inić-Kanada, Aleksandra and Lukić, Ivana and Dimitrijević, Ljiljana", year = "2012", abstract = "It has already been shown that tetanus toxoid (TTd) hyper-immunization is a suitable experimental method for creating the animal model of antiphospholipid syndrome (APS) in BALB/c mice. The severity of APS pathology in BALB/c mice mainly correlates to the affinity of anti-beta(2) glycoprotein I (beta(2)GPI) antibodies. In this study we have investigated reproductive pathology induced in C57BL/6 mice by TTd hyper-immunization using a combination of different pretreatments (complete Freund's adjuvant or glycerol) and adjuvants (alhydrogel or glycerol). A decrease in fecundity was recorded in only C57BL/6 mice immunized with alhydrogel adjuvant, irrespective of the kind of applied pretreatment; it was associated with an increase in abundance of low affinity anti-beta(2)GPI IgG antibodies and Th1 prevalence.", publisher = "Sage Publications Ltd, London", journal = "Innate Immunity", title = "Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant", pages = "342-333", number = "2", volume = "18", doi = "10.1177/1753425911407361" }
Živković, I., Petrušić, V., Stojanović, M., Inić-Kanada, A., Lukić, I.,& Dimitrijević, L.. (2012). Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant. in Innate Immunity Sage Publications Ltd, London., 18(2), 333-342. https://doi.org/10.1177/1753425911407361
Živković I, Petrušić V, Stojanović M, Inić-Kanada A, Lukić I, Dimitrijević L. Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant. in Innate Immunity. 2012;18(2):333-342. doi:10.1177/1753425911407361 .
Živković, Irena, Petrušić, Vladimir, Stojanović, Marijana, Inić-Kanada, Aleksandra, Lukić, Ivana, Dimitrijević, Ljiljana, "Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant" in Innate Immunity, 18, no. 2 (2012):333-342, https://doi.org/10.1177/1753425911407361 . .