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End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology

Authorized Users Only
2012
Authors
Dimitrijević, Mirjana
Stanojević, Stanislava
Kuštrimović, Nataša
Leposavić, Gordana
Article (Published version)
Metadata
Show full item record
Abstract
Much evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-point mediators. This suggests the important role of these mediators in immune system homeostasis and the pathogenesis of inflammatory autoimmune diseases. However, although it is clear that these mediators can modulate lymphocyte maturation and the activity of distinct immune cell types, their putative role in the pathogenesis of autoimmune disease is not yet completely understood. We have contributed to this field by discovering the influence of CAs and GCs on fine-tuning thymocyte negative selection and, in particular, by pointing to the putative CA-mediated mechanisms underlying this influence. Furthermore, we have shown that CAs are implicated in the regulation of regulatory T-cell development in the thymus. Moreover, our investigations related to macrophage biology emphasize the complex ...interaction between GCs, CAs and NPY in the modulation of macrophage functions and their putative significance for the pathogenesis of autoimmune inflammatory diseases.

Keywords:
Glucocorticoids / Catecholamines / Neuropeptide Y / Thymocyte negative selection / T regulatory cells / Macrophages / Autoimmune diseases / Experimental autoimmune encephalomyelitis
Source:
Immunologic Research, 2012, 52, 1-2, 64-80
Publisher:
  • Humana Press Inc, Totowa
Funding / projects:
  • Immune system plasticity during aging: Immunomodulatory capacity of oestrogens (RS-175050)

DOI: 10.1007/s12026-012-8275-9

ISSN: 0257-277X

PubMed: 22396175

WoS: 000303057600008

Scopus: 2-s2.0-84859917679
[ Google Scholar ]
14
10
URI
http://intor.torlakinstitut.com/handle/123456789/359
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Torlak
TY  - JOUR
AU  - Dimitrijević, Mirjana
AU  - Stanojević, Stanislava
AU  - Kuštrimović, Nataša
AU  - Leposavić, Gordana
PY  - 2012
UR  - http://intor.torlakinstitut.com/handle/123456789/359
AB  - Much evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-point mediators. This suggests the important role of these mediators in immune system homeostasis and the pathogenesis of inflammatory autoimmune diseases. However, although it is clear that these mediators can modulate lymphocyte maturation and the activity of distinct immune cell types, their putative role in the pathogenesis of autoimmune disease is not yet completely understood. We have contributed to this field by discovering the influence of CAs and GCs on fine-tuning thymocyte negative selection and, in particular, by pointing to the putative CA-mediated mechanisms underlying this influence. Furthermore, we have shown that CAs are implicated in the regulation of regulatory T-cell development in the thymus. Moreover, our investigations related to macrophage biology emphasize the complex interaction between GCs, CAs and NPY in the modulation of macrophage functions and their putative significance for the pathogenesis of autoimmune inflammatory diseases.
PB  - Humana Press Inc, Totowa
T2  - Immunologic Research
T1  - End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology
EP  - 80
IS  - 1-2
SP  - 64
VL  - 52
DO  - 10.1007/s12026-012-8275-9
UR  - conv_289
ER  - 
@article{
author = "Dimitrijević, Mirjana and Stanojević, Stanislava and Kuštrimović, Nataša and Leposavić, Gordana",
year = "2012",
abstract = "Much evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-point mediators. This suggests the important role of these mediators in immune system homeostasis and the pathogenesis of inflammatory autoimmune diseases. However, although it is clear that these mediators can modulate lymphocyte maturation and the activity of distinct immune cell types, their putative role in the pathogenesis of autoimmune disease is not yet completely understood. We have contributed to this field by discovering the influence of CAs and GCs on fine-tuning thymocyte negative selection and, in particular, by pointing to the putative CA-mediated mechanisms underlying this influence. Furthermore, we have shown that CAs are implicated in the regulation of regulatory T-cell development in the thymus. Moreover, our investigations related to macrophage biology emphasize the complex interaction between GCs, CAs and NPY in the modulation of macrophage functions and their putative significance for the pathogenesis of autoimmune inflammatory diseases.",
publisher = "Humana Press Inc, Totowa",
journal = "Immunologic Research",
title = "End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology",
pages = "80-64",
number = "1-2",
volume = "52",
doi = "10.1007/s12026-012-8275-9",
url = "conv_289"
}
Dimitrijević, M., Stanojević, S., Kuštrimović, N.,& Leposavić, G.. (2012). End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology. in Immunologic Research
Humana Press Inc, Totowa., 52(1-2), 64-80.
https://doi.org/10.1007/s12026-012-8275-9
conv_289
Dimitrijević M, Stanojević S, Kuštrimović N, Leposavić G. End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology. in Immunologic Research. 2012;52(1-2):64-80.
doi:10.1007/s12026-012-8275-9
conv_289 .
Dimitrijević, Mirjana, Stanojević, Stanislava, Kuštrimović, Nataša, Leposavić, Gordana, "End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology" in Immunologic Research, 52, no. 1-2 (2012):64-80,
https://doi.org/10.1007/s12026-012-8275-9 .,
conv_289 .

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