Two seasons' experience with pandemic A H1N1 influenza infection in neonates
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Martić, JelenaSavić, Nataša
Janković, Borisav
Nedeljković, Jasminka
Rakonjac, Zorika
Pejić, Katarina
Marković-Sovtić, Gordana
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There are only a few reports on influenza A H1N1 infection in neonates. In this paper, we present our additional experience on the clinical characteristics, epidemiology and treatment of influenza A H1N1 (2009) infection in 10 newborn infants (aged 9-24 days). Influenza A H1N1 infection was confirmed by real-time reverse transcription-polymerase chain reaction of the nasopharyngeal swab specimens. The majority of neonates presented with fever, respiratory symptoms and lethargy. The respiratory illness ranged from mild symptoms to severe pneumonia requiring mechanical ventilation. Antiviral treatment with oseltamivir was started in five patients (50%). One lethal outcome was observed, while nine patients (90%) had complete recovery. To our knowledge, this is the largest presented series of neonatal cases with different clinical symptoms. We discuss the necessity of initiation of oseltamivir in infants with different clinical features.
Keywords:
neonate / influenza / H1N1 / oseltamivirSource:
Turkish Journal of Pediatrics, 2012, 54, 6, 612-616Publisher:
- Turkish J Pediatrics, Ankara
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TorlakTY - JOUR AU - Martić, Jelena AU - Savić, Nataša AU - Janković, Borisav AU - Nedeljković, Jasminka AU - Rakonjac, Zorika AU - Pejić, Katarina AU - Marković-Sovtić, Gordana PY - 2012 UR - http://intor.torlakinstitut.com/handle/123456789/348 AB - There are only a few reports on influenza A H1N1 infection in neonates. In this paper, we present our additional experience on the clinical characteristics, epidemiology and treatment of influenza A H1N1 (2009) infection in 10 newborn infants (aged 9-24 days). Influenza A H1N1 infection was confirmed by real-time reverse transcription-polymerase chain reaction of the nasopharyngeal swab specimens. The majority of neonates presented with fever, respiratory symptoms and lethargy. The respiratory illness ranged from mild symptoms to severe pneumonia requiring mechanical ventilation. Antiviral treatment with oseltamivir was started in five patients (50%). One lethal outcome was observed, while nine patients (90%) had complete recovery. To our knowledge, this is the largest presented series of neonatal cases with different clinical symptoms. We discuss the necessity of initiation of oseltamivir in infants with different clinical features. PB - Turkish J Pediatrics, Ankara T2 - Turkish Journal of Pediatrics T1 - Two seasons' experience with pandemic A H1N1 influenza infection in neonates EP - 616 IS - 6 SP - 612 VL - 54 UR - https://hdl.handle.net/21.15107/rcub_intor_348 ER -
@article{ author = "Martić, Jelena and Savić, Nataša and Janković, Borisav and Nedeljković, Jasminka and Rakonjac, Zorika and Pejić, Katarina and Marković-Sovtić, Gordana", year = "2012", abstract = "There are only a few reports on influenza A H1N1 infection in neonates. In this paper, we present our additional experience on the clinical characteristics, epidemiology and treatment of influenza A H1N1 (2009) infection in 10 newborn infants (aged 9-24 days). Influenza A H1N1 infection was confirmed by real-time reverse transcription-polymerase chain reaction of the nasopharyngeal swab specimens. The majority of neonates presented with fever, respiratory symptoms and lethargy. The respiratory illness ranged from mild symptoms to severe pneumonia requiring mechanical ventilation. Antiviral treatment with oseltamivir was started in five patients (50%). One lethal outcome was observed, while nine patients (90%) had complete recovery. To our knowledge, this is the largest presented series of neonatal cases with different clinical symptoms. We discuss the necessity of initiation of oseltamivir in infants with different clinical features.", publisher = "Turkish J Pediatrics, Ankara", journal = "Turkish Journal of Pediatrics", title = "Two seasons' experience with pandemic A H1N1 influenza infection in neonates", pages = "616-612", number = "6", volume = "54", url = "https://hdl.handle.net/21.15107/rcub_intor_348" }
Martić, J., Savić, N., Janković, B., Nedeljković, J., Rakonjac, Z., Pejić, K.,& Marković-Sovtić, G.. (2012). Two seasons' experience with pandemic A H1N1 influenza infection in neonates. in Turkish Journal of Pediatrics Turkish J Pediatrics, Ankara., 54(6), 612-616. https://hdl.handle.net/21.15107/rcub_intor_348
Martić J, Savić N, Janković B, Nedeljković J, Rakonjac Z, Pejić K, Marković-Sovtić G. Two seasons' experience with pandemic A H1N1 influenza infection in neonates. in Turkish Journal of Pediatrics. 2012;54(6):612-616. https://hdl.handle.net/21.15107/rcub_intor_348 .
Martić, Jelena, Savić, Nataša, Janković, Borisav, Nedeljković, Jasminka, Rakonjac, Zorika, Pejić, Katarina, Marković-Sovtić, Gordana, "Two seasons' experience with pandemic A H1N1 influenza infection in neonates" in Turkish Journal of Pediatrics, 54, no. 6 (2012):612-616, https://hdl.handle.net/21.15107/rcub_intor_348 .